Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269892 | 0.76 | PIK3CA (0.57) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL12427503 | 0.64 | LATS1 (0.37) | LATS1LATS2MAPK1 | |
| SCHEMBL10239932 | 0.62 | MAP3K12 (0.41) | MAP3K12PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22256141 | 0.61 | TLR8 (0.38) | NLRP3GAKMAPK1 | |
| SCHEMBL2269763 | 0.60 | PIK3CA (0.59) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2272652 | 0.59 | PIK3R1 (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGGAK | |
| SCHEMBL4446943 | 0.58 | PIK3CA (0.64) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23472667 | 0.58 | TNF (0.49) | — | |
| SCHEMBL29785073 | 0.57 | EGLN2 (0.35) | MAP3K12MAPK1 | |
| SCHEMBL14913101 | 0.57 | CHRNB2 (0.42) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101429-A1 | PYRIDO[3,2-D]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |