Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 2/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276345 | 0.72 | PIK3CA (0.60) | — | |
| SCHEMBL14342919 | 0.61 | PIK3CA (0.49) | ALDH1A1CYP2C19TSHR | |
| SCHEMBL29790493 | 0.59 | TLR8 (0.71) | MAPK1ALDH1A1TLR8TLR7KDM4E | |
| SCHEMBL17076589 | 0.59 | L3MBTL1 (0.36) | MAPK1ALDH1A1L3MBTL1PIM1KDM4E | |
| SCHEMBL18124725 | 0.59 | TLR8 (0.71) | MAPK1ALDH1A1TLR8TLR7KDM4E | |
| SCHEMBL22256141 | 0.58 | TLR8 (0.38) | MAPK1KCNH2PTPN1TLR8TLR7 | |
| SCHEMBL16465803 | 0.58 | NUDT1 (0.41) | MAPK1ALDH1A1KCNH2L3MBTL1PIM1 | |
| SCHEMBL3159641 | 0.58 | NUDT1 (0.43) | MAPK1ALDH1A1PTPN1L3MBTL1CYP2C19 | |
| SCHEMBL29625490 | 0.58 | NUDT1 (0.69) | ALDH1A1ALOX5APFEN1L3MBTL1PIM1 | |
| SCHEMBL29154 | 0.58 | NUDT1 (0.69) | ALDH1A1ALOX5APFEN1L3MBTL1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101429-A1 | PYRIDO[3,2-D]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |