Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ILK | Q13418 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22256208 | 0.93 | TLR8 (0.41) | TLR8TLR7NLRP3SYKAURKB | |
| SCHEMBL22234541 | 0.83 | GAK (0.34) | SYKAURKBGAKKDM4ECYP2C19 | |
| SCHEMBL22256210 | 0.82 | PGK1 (0.41) | TLR8TLR7NLRP3KCNH2 | |
| SCHEMBL22256209 | 0.82 | APP (0.36) | TLR8TLR7NLRP3 | |
| SCHEMBL22249446 | 0.80 | CHUK (0.40) | CHUKSYKPTPN1ILKKDM4E | |
| SCHEMBL22249445 | 0.80 | CHUK (0.40) | CHUKSYKKCNH2PTPN1ILK | |
| SCHEMBL22256195 | 0.79 | DHFR (0.38) | AURKB | |
| SCHEMBL22234377 | 0.79 | GAK (0.34) | SYKGAKKDM4ECYP2D6CYP2C19 | |
| SCHEMBL22234500 | 0.78 | CYP2D6 (0.42) | TLR7CHUKGAKCYP2D6 | |
| SCHEMBL22234274 | 0.77 | NLRP3 (0.47) | NLRP3SYKKCNH2ILKPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220087991-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY INC (US) | 2022-03-24 | — | — | US | disclosed |
| WO-2020150114-A1 | HETEROCYCLIC NLRP3 MODULATORS, FOR USE IN THE TREATMENT OF CANCER | INNATE TUMOR IMMUNITY, INC. (US) | 2020-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220087991-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, PYCARD | TLR8 210/4885TLR7 236/4885CHUK 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.