Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.35 |
| ▸ | PI4KA | P42356 | 3/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 4/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047375 | 0.98 | ADORA2A (0.37) | AADATADORA2API4KBADORA3ADORA1 | |
| SCHEMBL26782831 | 0.80 | HPGD (0.40) | AADATBTKACHEHPGDALDH1A1 | |
| SCHEMBL31078355 | 0.80 | AADAT (0.36) | AADATADORA2API4KBADORA3ADORA1 | |
| SCHEMBL25719671 | 0.79 | AADAT (0.38) | AADATADORA2API4KBPI4KAPI4K2B | |
| SCHEMBL17047825 | 0.76 | AADAT (0.39) | AADATADORA2AADORA3ADORA1BTK | |
| SCHEMBL174443 | 0.76 | PKM (0.38) | AADATADORA2API4KBADORA3ADORA1 | |
| SCHEMBL175153 | 0.74 | BTK (0.52) | AADATBTKACHE | |
| SCHEMBL12428905 | 0.74 | HPGD (0.33) | AADATADORA2API4KBADORA3ADORA1 | |
| SCHEMBL2077014 | 0.74 | PKM (0.40) | AADATADORA2API4KBPI4KAPI4K2B | |
| SCHEMBL12800678 | 0.74 | BTK (0.43) | AADATADORA2AADORA1BTKACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351751-A1 | Substituted pyrazolopyrimidines | CEPHALON, INC. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2008063232-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |