Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 3/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 4/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047375 | 0.77 | ADORA2A (0.37) | HPGDAADATPI4KAPI4K2BPI4K2A | |
| SCHEMBL12427508 | 0.74 | AADAT (0.37) | HPGDAADATPI4KAPI4K2BPI4K2A | |
| SCHEMBL12779158 | 0.71 | BTK (0.41) | AADATBMPR1AACVRL1ACVR1BTK | |
| SCHEMBL2077014 | 0.70 | PKM (0.40) | AADATPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL24538727 | 0.69 | BTK (0.51) | AADATBMPR1AACVRL1ACVR1BTK | |
| SCHEMBL26782831 | 0.68 | HPGD (0.40) | HPGDAADATBTKCTSKKDM4E | |
| SCHEMBL174443 | 0.68 | PKM (0.38) | AADATPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL25719671 | 0.67 | AADAT (0.38) | HPGDAADATPI4KAPI4K2BPI4K2A | |
| SCHEMBL175153 | 0.67 | BTK (0.52) | AADATBTK | |
| SCHEMBL22258794 | 0.66 | ALDH1A1 (0.41) | HPGDAADATKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351751-A1 | Substituted pyrazolopyrimidines | CEPHALON, INC. (US) | 2011-08-03 | — | — | EP | disclosed |