Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427684 | 0.94 | CHRM2 (0.44) | PRKCAMMP12NR1I2SCN9ACHRM2 | |
| SCHEMBL10283491 | 0.91 | PRKCA (0.44) | PRKCAMMP12NR1I2SCN9ACHRM2 | |
| SCHEMBL804193 | 0.91 | PRKCA (0.42) | PRKCAMMP12NR1I2SCN9AALDH1A1 | |
| SCHEMBL10283262 | 0.90 | PRKCA (0.48) | PRKCAMMP12NR1I2SCN9ACHRM2 | |
| SCHEMBL12427739 | 0.89 | PRKCA (0.42) | PRKCAMMP12NR1I2SCN9ACHRM2 | |
| SCHEMBL12427674 | 0.89 | PRKCA (0.43) | PRKCAMMP12NR1I2SCN9A | |
| SCHEMBL12428861 | 0.88 | PRKCA (0.43) | PRKCAMMP12NR1I2SCN9ACHRM2 | |
| SCHEMBL10283493 | 0.88 | PRKCA (0.43) | PRKCAMMP12NR1I2SCN9AALDH1A1 | |
| SCHEMBL803809 | 0.87 | PRKCA (0.46) | PRKCAMMP12NR1I2SCN9ACHRM2 | |
| SCHEMBL12428400 | 0.87 | PRKCA (0.42) | PRKCAMMP12NR1I2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |