Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | VDR | P11473 | 4/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.34 |
| ▸ | ESR1 | P03372 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.34 |
| ▸ | GLP1R | P43220 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428350 | 0.92 | PRKCA (0.46) | PRKCAMMP12ROCK2VDRNR1H4 | |
| SCHEMBL12428167 | 0.89 | PRKCA (0.38) | PRKCAMMP12ROCK2VDRNR1H4 | |
| SCHEMBL804548 | 0.88 | L3MBTL1 (0.42) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL10283614 | 0.88 | PRKCA (0.42) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL12427985 | 0.88 | PRKCA (0.42) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL792699 | 0.87 | PRKCA (0.41) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL10283489 | 0.87 | EGFR (0.44) | PRKCAMMP12 | |
| SCHEMBL12427623 | 0.86 | PRKCA (0.43) | PRKCAMMP12SCN9AKCNH2 | |
| SCHEMBL12428492 | 0.86 | PRKCA (0.37) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL12428343 | 0.86 | POLB (0.43) | PRKCAMMP12SCN9AESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |