SCHEMBL12428996

SCHEMBL12428996

Bc1ccc(-c2ncccn2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK4 Q9HAZ1 3/20 0.52
ADRB2 P07550 2/20 0.52
CYP2A6 P11509 1/20 0.44
DYRK1A Q13627 1/20 0.38
NPC1 O15118 6/20 0.37
RAB9A P51151 6/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
NFKB1 P19838 2/20 0.37
NFKB2 Q00653 2/20 0.37
RELA Q04206 2/20 0.37
PIK3CD O00329 1/20 0.36
PIP5K1C O60331 1/20 0.36
PI4KA P42356 1/20 0.36
PIK3CG P48736 1/20 0.36
PI4KB Q9UBF8 1/20 0.36
AOC3 Q16853 2/20 0.36
HDAC4 P56524 2/20 0.36
CYP3A4 P08684 1/20 0.36
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6685962 0.86 CLK4 (0.64) CLK4ADRB2CYP2A6DYRK1ANPC1
SCHEMBL16625771 0.83 CLK4 (0.61) CLK4ADRB2CYP2A6DYRK1ANPC1
SCHEMBL20068646 0.79 RAB9A (0.44) CLK4ADRB2CYP2A6NPC1RAB9A
SCHEMBL29637612 0.76 CLK4 (0.54) CLK4ADRB2CYP2A6DYRK1ANPC1
SCHEMBL29637613 0.76 CLK4 (0.54) CLK4ADRB2CYP2A6DYRK1ANPC1
SCHEMBL29637614 0.76 CLK4 (0.54) CLK4ADRB2CYP2A6DYRK1ANPC1
SCHEMBL3157659 0.76 RAB9A (0.64) CLK4ADRB2CYP2A6NPC1RAB9A
SCHEMBL14040329 0.75 NPC1 (0.75) NPC1RAB9ASMN1; SMN2NFKB1NFKB2
SCHEMBL28062294 0.75 NPC1 (0.62) CLK4ADRB2CYP2A6DYRK1ANPC1
SCHEMBL33833 0.75 NPC1 (0.62) CLK4ADRB2CYP2A6DYRK1ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2351750-A1 1,3,5-TRIAZINE DERIVATIVE, PROCESS FOR PRODUCING SAME, AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME AS CONSTITUENT COMPONENT Tosoh Corporation (JP) 2011-08-03 EP disclosed
WO-2010038854-A1 1,3,5-TRIAZINE DERIVATIVE, PROCESS FOR PRODUCING SAME, AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME AS CONSTITUENT COMPONENT 東ソー株式会社 (JP) 2010-04-08 WO disclosed