Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | ANPEP | P15144 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30591269 | 0.82 | SMN1; SMN2 (0.36) | MMP2ANPEPSMN1; SMN2 | |
| SCHEMBL3429014 | 0.82 | SMN1; SMN2 (0.36) | MMP2ANPEPSMN1; SMN2 | |
| SCHEMBL4146529 | 0.81 | MMP2 (0.35) | MMP2ANPEPSMN1; SMN2ALDH1A1 | |
| SCHEMBL19964285 | 0.81 | MMP2 (0.35) | MMP2ANPEPSMN1; SMN2ALDH1A1 | |
| SCHEMBL13435552 | 0.81 | MMP2 (0.35) | MMP2ANPEPSMN1; SMN2ALDH1A1 | |
| SCHEMBL14013930 | 0.81 | ALDH1A1 (0.54) | MMP2ANPEPCYP19A1ALDH1A1KMT2A | |
| SCHEMBL2197971 | 0.80 | TRPA1 (0.41) | MMP2ANPEPALDH1A1KMT2A | |
| SCHEMBL2197974 | 0.80 | TRPA1 (0.41) | MMP2ANPEPALDH1A1KMT2A | |
| SCHEMBL4139942 | 0.78 | MMP2 (0.52) | MMP2ANPEPALDH1A1 | |
| SCHEMBL15130169 | 0.78 | MMP2 (0.39) | MMP2ANPEPSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977368-B2 | Pyrazolopyrrolidines as inhibitors of gamma secretase | ELAN PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090099235-A1 | Pyrazolopyrrolidines as Inhibitors of Gamma Secretase | ELAN PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099235-A1 | Pyrazolopyrrolidines as Inhibitors of Gamma Secretase | BACE1, BACE2, APP | MMP2 2946/4885ANPEP 878/4885TP53 1186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.