Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12433224 | 0.88 | PKM (0.41) | GAAPOLBABCB1ABCC1MEN1 | |
| SCHEMBL1390513 | 0.87 | KDM4E (0.50) | GAAPOLBNPC1MAPTRAB9A | |
| SCHEMBL1390514 | 0.87 | KDM4E (0.50) | GAAPOLBNPC1MAPTRAB9A | |
| SCHEMBL12433192 | 0.84 | KMT2A (0.57) | GAAPOLBNPC1MAPTRAB9A | |
| SCHEMBL12432828 | 0.83 | HRH2 (0.42) | GAAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL12433326 | 0.82 | IDO1 (0.54) | GAAPOLBNPC1MAPTRAB9A | |
| SCHEMBL3715569 | 0.81 | POLB (0.67) | POLBNPC1MAPTRAB9AMEN1 | |
| SCHEMBL1390968 | 0.80 | MEN1 (0.47) | GAAPOLBNPC1MAPTRAB9A | |
| SCHEMBL1390872 | 0.76 | KDM4E (0.53) | MAPTABCB1ABCC1MEN1KMT2A | |
| SCHEMBL1390875 | 0.76 | KDM4E (0.53) | MAPTABCB1ABCC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351743-A1 | BICYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-08-03 | — | — | EP | disclosed |