Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PHPT1 | Q9NRX4 | 1/20 | 0.45 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19405908 | 0.87 | NPC1 (0.50) | POLBNPC1MAPTRAB9APRKCI | |
| 3-Hydroxy-4-Acetylaminobenzoic Acid SCHEMBL8018270 | 0.87 | MAPT (0.65) | POLBNPC1MAPTRAB9AALDH1A1 | |
| 3-Hydroxy-4-Acetylaminobenzoic Acid SCHEMBL31026207 | 0.87 | MAPT (0.65) | POLBNPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL1544846 | 0.85 | POLB (0.57) | POLBNPC1MAPTRAB9APRKCI | |
| SCHEMBL4218090 | 0.84 | ALDH1A1 (0.64) | POLBNPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL4958020 | 0.82 | MAPT (0.69) | POLBNPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL1108312 | 0.82 | PRKCI (0.65) | POLBNPC1MAPTRAB9APRKCI | |
| SCHEMBL3362895 | 0.81 | ALDH1A1 (0.55) | POLBNPC1MAPTRAB9APRKCI | |
| SCHEMBL30275453 | 0.81 | ALDH1A1 (0.55) | POLBNPC1MAPTRAB9APRKCI | |
| SCHEMBL12432308 | 0.81 | GAA (0.46) | POLBNPC1MAPTRAB9APRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129467-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129467-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |