Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12432821 | 0.88 | GAA (0.56) | KMT2AMEN1GAANPC1RAB9A | |
| SCHEMBL12432308 | 0.84 | GAA (0.46) | KMT2AMEN1GAANPC1RAB9A | |
| SCHEMBL1390968 | 0.81 | MEN1 (0.47) | KMT2AMEN1GAANPC1RAB9A | |
| SCHEMBL6836298 | 0.81 | KMT2A (0.63) | KMT2AMEN1CXCR2GAANPC1 | |
| SCHEMBL1390513 | 0.80 | KDM4E (0.50) | KMT2AMEN1GAANPC1RAB9A | |
| SCHEMBL1390514 | 0.80 | KDM4E (0.50) | KMT2AMEN1GAANPC1RAB9A | |
| SCHEMBL4520067 | 0.80 | NPC1 (0.69) | KMT2AMEN1CXCR2GAANPC1 | |
| SCHEMBL4972469 | 0.77 | KMT2A (0.58) | KMT2AMEN1CXCR2GAANPC1 | |
| SCHEMBL12125127 | 0.77 | KMT2A (0.58) | KMT2AMEN1CXCR2GAANPC1 | |
| SCHEMBL12433224 | 0.75 | PKM (0.41) | KMT2AMEN1GAAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351743-A1 | BICYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-08-03 | — | — | EP | disclosed |