Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HBB | P68871 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315656 | 0.84 | BCHE (0.69) | DRD4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL4269129 | 0.83 | KDM4E (0.47) | POLBALDH1A1MC4RKMT2AMEN1 | |
| SCHEMBL12432723 | 0.83 | KMT2A (0.60) | DRD2ALDH1A1KMT2A | |
| SCHEMBL3378826 | 0.82 | MAPK1 (0.53) | ALDH1A1ACHEKMT2AMEN1 | |
| SCHEMBL9720752 | 0.78 | DRD4 (0.77) | DRD4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL15314567 | 0.77 | ACHE (0.62) | DRD4DRD2DRD3POLBALDH1A1 | |
| SCHEMBL12432730 | 0.77 | SIGMAR1 (0.57) | DRD4DRD2DRD3SIGMAR1LMNA | |
| Methyl Alcohol SCHEMBL27657573 | 0.76 | SIGMAR1 (0.86) | DRD4SIGMAR1LMNAPOLBALDH1A1 | |
| SCHEMBL11889012 | 0.75 | S1PR1 (0.52) | POLBALDH1A1S1PR1S1PR5 | |
| SCHEMBL2310308 | 0.75 | SIGMAR1 (0.69) | DRD4DRD2DRD3SIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893207-B1 | USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-08-03 | — | — | EP | disclosed |