SCHEMBL2315656

SCHEMBL2315656

Oc1ccc(CN2CCN(Cc3ccccc3)CC2)c(O)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 3/20 0.69
ACHE P22303 3/20 0.69
BACE1 P56817 3/20 0.69
SIGMAR1 Q99720 3/20 0.58
DRD4 P21917 1/20 0.58
DRD2 P14416 1/20 0.57
DRD3 P35462 1/20 0.57
ALOX5 P09917 1/20 0.57
LMNA P02545 2/20 0.56
ALDH1A1 P00352 2/20 0.56
HTT P42858 1/20 0.56
MPO P05164 1/20 0.56
ALOX15 P16050 2/20 0.55
USP2 O75604 1/20 0.55
TP53 P04637 1/20 0.55
NFKB1 P19838 1/20 0.55
NFKB2 Q00653 1/20 0.55
RELA Q04206 1/20 0.55
HPGD P15428 1/20 0.54
HBB P68871 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12433148 0.84 DRD4 (0.55) BCHEACHEBACE1SIGMAR1DRD4
SCHEMBL9785819 0.83 ALDH1A1 (0.57) BCHEACHEBACE1LMNAALDH1A1
SCHEMBL21658466 0.83 MPO (0.81) BCHEACHEBACE1SIGMAR1DRD4
Hydrochloric Acid SCHEMBL9785760 0.82 ALDH1A1 (0.56) BCHEACHEBACE1LMNAALDH1A1
SCHEMBL9720752 0.81 DRD4 (0.77) ACHEBACE1SIGMAR1DRD4DRD2
SCHEMBL2313324 0.80 GFER (0.50) BCHEACHEBACE1DRD2ALOX5
SCHEMBL2310308 0.78 SIGMAR1 (0.69) SIGMAR1DRD4DRD2DRD3LMNA
SCHEMBL2311369 0.77 TYR (0.47) BCHEACHEBACE1SIGMAR1LMNA
SCHEMBL10398153 0.77 CYP2C9 (0.66) BCHEACHEBACE1LMNAALDH1A1
SCHEMBL2489199 0.76 SIGMAR1 (1.00) ACHESIGMAR1DRD4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893207-B1 USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2011-08-03 EP disclosed
EP-1893207-B1 USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2011-08-03 EP disclosed
EP-1893207-A1 USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES Merck Patent GmbH (DE) 2008-03-05 EP disclosed
WO-2006133784-A1 USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2006-12-21 WO disclosed