Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27877164 | 0.86 | CXCR2 (0.67) | NPC1RAB9AMAPTPOLBCXCR2 | |
| SCHEMBL1224549 | 0.84 | KCNMA1 (0.62) | NPC1RAB9AMAPTPOLBGAA | |
| SCHEMBL6836389 | 0.82 | CXCR2 (0.63) | NPC1RAB9AMAPTPOLBCXCR2 | |
| SCHEMBL22782181 | 0.82 | HPGD (0.72) | NPC1RAB9AMAPTPOLBCXCR2 | |
| SCHEMBL2896946 | 0.82 | POLB (0.71) | NPC1RAB9AMAPTPOLBGAA | |
| SCHEMBL2306741 | 0.82 | KMT2A (0.69) | NPC1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL11720879 | 0.82 | POLB (1.00) | NPC1RAB9AMAPTPOLBGAA | |
| SCHEMBL18131322 | 0.82 | TDP1 (0.52) | NPC1RAB9AMAPTPOLBKMT2A | |
| SCHEMBL6836537 | 0.81 | CXCR2 (0.49) | NPC1RAB9AMAPTPOLBCXCR2 | |
| SCHEMBL12433192 | 0.80 | KMT2A (0.57) | NPC1RAB9AMAPTPOLBCXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6752839-B1 | 2-SUBSTITUTED 5-AMINOALKYLPHENOL DERIVATIVE COUPLER AND PYRAZOLES, CERTAIN PYRIMIDINES AND/OR PYRAZOLOPYRIMIDINES BASES; CHROMATIC, STRONG, AESTHETIC COLORATIONS IN VARIETY OF SHADES | L'OREAL (FR) | 2004-06-22 | — | — | US | claimed |
| US-6530960-B1 | Oxidative base at least one 2-substituted 5-aminoalkylphenol coupler; chromatic, strong, aesthetic colorations in a variety of shades | L'OREAL S.A. (FR) | 2003-03-11 | — | — | US | claimed |
| EP-1093788-A1 | Oxydative dyeing composition for keratinic fibres and dyeing process using this composition | L'OREAL (FR) | 2001-04-25 | — | — | EP | claimed |
| EP-1093791-A1 | Composition for oxidative dyeing of keratinous fibres and dyeing process using same | L'OREAL (FR) | 2001-04-25 | — | — | EP | claimed |
| EP-1093793-A2 | Composition for oxidative dyeing of keratinous fibres and dyeing process using same | L'OREAL (FR) | 2001-04-25 | — | — | EP | claimed |
| EP-1093790-A2 | Oxydative dyeing composition for keratinic fibres and dyeing process using this composition | L'OREAL (FR) | 2001-04-25 | — | — | EP | claimed |
| EP-1093792-A1 | Composition for oxidative dyeing of keratinous fibres and dyeing process using the same | L'OREAL (FR) | 2001-04-25 | — | — | EP | claimed |
| EP-1093789-A1 | Composition for oxidative dyeing of keratinous fibres and dyeing process using the same | L'OREAL (FR) | 2001-04-25 | — | — | EP | claimed |
| WO-1999001607-A2 | ENZYMATIC OXIDATION SYSTEM WITH NOVEL ENZYMATIC-EFFECT ENHANCING COMPOUNDS | CALL, KRIMHILD (DE) | 1999-01-14 | — | — | WO | claimed |
| WO-2019050988-A1 | VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO | BLACKTHORN THERAPEUTICS, INC. (US) | 2019-03-14 | — | — | WO | disclosed |
| US-9096527-B2 | TRPM8 antagonists and their use in treatments | AMGEN INC. (US) | 2015-08-04 | — | — | US | disclosed |
| EP-2376492-B1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-04-08 | — | — | EP | disclosed |
| US-8952009-B2 | Chroman derivatives as TRPM8 inhibitors | AMGEN INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-20150031668-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC (US) | 2015-01-29 | — | — | US | disclosed |
| US-4258127-A | PHOTOGRAPHY, FOGGING | FUJI PHOTO FILM CO., LTD. (JP) | 1981-03-24 | — | — | US | disclosed |
| US-4247488-A | Process for the preparation of 1-oxophosphol-Δ3 -enes | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-01-27 | — | — | US | disclosed |
| US-RE30267-E | SEMIPERMEABLE MEMBRANE, THIN FILM | EASTMAN KODAK COMPANY (US) | 1980-05-06 | — | — | US | disclosed |
| US-4066403-A | DECOMPOSITION, PERMEABLE BARRIERS | EASTMAN KODAK COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-3997348-A | FERRIC SALT BLEACHING SOLUTION | FUJI PHOTO FILM CO., LTD. (JA) | 1976-12-14 | — | — | US | disclosed |
| US-3948659-A | BLEACHING | FUJI PHOTO FILM CO., LTD. (JA) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031668-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | TRPM8, TRPM5, TRPM7 | NPC1 702/4885RAB9A 1056/4885MAPT 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.