Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2267443 | 0.76 | CHRNB2 (0.43) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| SCHEMBL2268013 | 0.66 | KDM4E (0.59) | ALDH1A1TSHRKMT2AMEN1LMNA | |
| SCHEMBL23240567 | 0.66 | KMT2A (0.39) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| SCHEMBL7885985 | 0.66 | RXFP1 (0.55) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| SCHEMBL17813483 | 0.65 | LMNA (0.45) | ALDH1A1TSHRKMT2AMEN1LMNA | |
| SCHEMBL11160869 | 0.64 | LMNA (0.59) | TSHRKMT2AMEN1LMNAPABPC1 | |
| SCHEMBL387339 | 0.63 | ALDH1A1 (0.54) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| SCHEMBL8226758 | 0.63 | CHRNB2 (0.39) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| SCHEMBL23103463 | 0.63 | CHEK1 (0.35) | ALDH1A1TSHRLMNAGAAHSD17B10 | |
| SCHEMBL16221674 | 0.62 | HTT (0.40) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092293-A2 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-04 | — | — | WO | disclosed |