Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 12/20 | 0.53 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1243591 | 0.81 | INSR (0.52) | INSRSNCAADRB2ADRB1MAPT | |
| Iodide SCHEMBL6246881 | 0.76 | INSR (0.70) | INSRSNCAADRB2ADRB1MAPT | |
| SCHEMBL1245835 | 0.75 | CHAT (0.59) | MAPTNSD2POLBMAPK1HTT | |
| Iodide SCHEMBL1243612 | 0.74 | SNCA (0.45) | INSRSNCAADRB2ADRB1MAPT | |
| Hydrochloric Acid SCHEMBL1246670 | 0.74 | CHAT (0.57) | MAPTNSD2POLBMAPK1HTT | |
| Hydrochloric Acid SCHEMBL1246731 | 0.72 | POLB (0.51) | MAPTPOLBHTTRAB9ANPSR1 | |
| SCHEMBL8386574 | 0.72 | INSR (0.73) | INSRSNCAMAPTNSD2POLB | |
| SCHEMBL17471889 | 0.72 | INSR (0.61) | INSRSNCAADRB2ADRB1MAPT | |
| SCHEMBL8386579 | 0.72 | INSR (0.73) | INSRSNCAMAPTNSD2POLB | |
| Iodide SCHEMBL1244938 | 0.72 | INSR (0.50) | INSRMAPTPOLBHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459733-B1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-08 | — | — | EP | claimed |
| US-8535902-B2 | Peptidase substrates | bioMërieux, S.A. | 2013-09-17 | — | — | US | claimed |
| EP-2459733-A2 | NOVEL PEPTIDASE SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | claimed |
| US-20120129203-A1 | Novel Peptidase Substrates | bioMerieux, SA (FR) | 2012-05-24 | — | — | US | claimed |
| WO-2011012807-A2 | NOVEL PEPTIDASE SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | claimed |
| EP-2459733-B1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-08 | — | — | EP | disclosed |
| US-8535902-B2 | Peptidase substrates | bioMërieux, S.A. | 2013-09-17 | — | — | US | disclosed |
| EP-2459733-A2 | NOVEL PEPTIDASE SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | disclosed |
| US-20120129203-A1 | Novel Peptidase Substrates | bioMerieux, SA (FR) | 2012-05-24 | — | — | US | disclosed |
| WO-2011012807-A2 | NOVEL PEPTIDASE SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129203-A1 | Novel Peptidase Substrates | CTRL, CPB1, ANPEP | INSR 340/4885SNCA 4665/4885ADRB2 3540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.