Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CHAT | P28329 | 3/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1246032 | 0.90 | POLB (0.51) | POLBAPOBEC3AAPOBEC3GKMT2ACTDSP1 | |
| SCHEMBL13043430 | 0.82 | POLB (0.51) | POLBAPOBEC3AAPOBEC3GKMT2ACTDSP1 | |
| SCHEMBL13043431 | 0.80 | POLB (0.49) | POLBAPOBEC3AAPOBEC3GKMT2ACTDSP1 | |
| SCHEMBL13764751 | 0.79 | POLB (0.46) | POLBAPOBEC3AAPOBEC3GKMT2ACTDSP1 | |
| Hydrochloric Acid SCHEMBL1246670 | 0.77 | CHAT (0.57) | POLBAPOBEC3AAPOBEC3GKMT2ACTDSP1 | |
| SCHEMBL1246036 | 0.77 | TAAR1 (0.51) | POLBAPOBEC3AAPOBEC3GKMT2ACTDSP1 | |
| SCHEMBL16492610 | 0.76 | CA1 (0.47) | KMT2ACA1CA2KDM4ETERT | |
| SCHEMBL1245835 | 0.75 | CHAT (0.59) | POLBAPOBEC3AAPOBEC3GKMT2ACTDSP1 | |
| SCHEMBL8008080 | 0.75 | CA1 (0.57) | KMT2ACA1CA2ALDH1A1KDM4E | |
| SCHEMBL20195629 | 0.74 | CA1 (0.56) | POLBKMT2ACA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459735-B1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-08 | — | — | EP | claimed |
| US-8535901-B2 | Peptidase substrates | bioMérieux, S.A. | 2013-09-17 | — | — | US | claimed |
| EP-2459735-A2 | NOVEL PEPTIDASE SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | claimed |
| US-20120122134-A1 | Novel Peptidase Substrates | BIOMERIEUX SA (FR) | 2012-05-17 | — | — | US | claimed |
| WO-2011012811-A2 | NOVEL PEPTIDASE SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | claimed |
| EP-2459735-B1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-08 | — | — | EP | disclosed |
| US-8535901-B2 | Peptidase substrates | bioMérieux, S.A. | 2013-09-17 | — | — | US | disclosed |
| EP-2459735-A2 | NOVEL PEPTIDASE SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | disclosed |
| US-20120122134-A1 | Novel Peptidase Substrates | BIOMERIEUX SA (FR) | 2012-05-17 | — | — | US | disclosed |
| WO-2011012811-A2 | NOVEL PEPTIDASE SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122134-A1 | Novel Peptidase Substrates | CPA4, CTRL, CPB1 | POLB 4267/4885APOBEC3A 3456/4885APOBEC3G 2774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.