SCHEMBL124354

SCHEMBL124354

NNc1cc(F)ccc1F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
CA9 Q16790 2/20 0.42
CA3 P07451 1/20 0.42
CA6 P23280 1/20 0.42
CA5A P35218 1/20 0.42
CA14 Q9ULX7 1/20 0.42
CA5B Q9Y2D0 1/20 0.42
MAPT P10636 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
PKM P14618 2/20 0.39
HTT P42858 2/20 0.39
POLB P06746 1/20 0.39
DHFR P00374 1/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
KDM1A O60341 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29544738 1.00 ALDH1A1 (0.42) ALDH1A1CA9CA3CA6CA5A
Hydrochloric Acid SCHEMBL1408624 0.98 MAPT (0.41) ALDH1A1CA9CA3CA6CA5A
Hydrogen Sulfide SCHEMBL28200717 0.98 MAPT (0.41) ALDH1A1CA9CA3CA6CA5A
Hydrochloric Acid SCHEMBL29502148 0.98 MAPT (0.41) ALDH1A1CA9CA3CA6CA5A
Phosphine SCHEMBL28200789 0.98 MAPT (0.41) ALDH1A1CA9CA3CA6CA5A
Bromide SCHEMBL20984147 0.98 MAPT (0.41) ALDH1A1CA9CA3CA6CA5A
Oxalic Acid SCHEMBL20984172 0.88 MAPT (0.46) ALDH1A1CA9CA3CA6CA5A
Phosphoric Acid SCHEMBL20984126 0.88 MAPT (0.43) ALDH1A1CA9CA3CA6CA5A
Sulfuric Acid SCHEMBL20984178 0.88 CA9 (0.44) ALDH1A1CA9CA3CA6CA5A
Nitric Acid SCHEMBL20984812 0.84 ATM (0.43) ALDH1A1CA9CA3CA6CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110003160-B Osthole hydrazone/acylhydrazone/sulfonylhydrazone derivatives, and preparation method and application thereof 贵州中医药大学 2022-10-11 CN claimed
CN-110003160-A A kind of Osthole hydrazone class/acylhydrazone class/sulphur acylhydrazone and preparation method thereof and application 贵州中医药大学 2019-07-12 CN claimed
US-6797745-B1 Hot melt inks containing styrene or terpene polymers XEROX CORPORATION 2004-09-28 US claimed
US-5897940-A Ink jet transparencies XEROX CORPORATION (US) 1999-04-27 US claimed
US-5744273-A Laminatable backing substrates containing fluoro compounds for improved toner flow XEROX CORPORATION (US) 1998-04-28 US claimed
US-20260132147-A1 BAX INHIBITORS AND USES THEREOF CASE WESTERN RESERVE UNIV (US) 2026-05-14 US disclosed
US-12497394-B2 Fused-cyclic pyrazolone formamide compound and preparation method therefor, pharmaceutical composition and use thereof SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2025-12-16 US disclosed
US-12479857-B2 Bax inhibitors and uses thereof CASE WESTERN RESERVE UNIVERSITY (US) 2025-11-25 US disclosed
EP-4587433-A1 3-(1H-INDOLE-2-CARBONYL)-6,6-DIMETHYL-N-((S)-1-OXO-3-((S)-2-OXOPYRROLIDIN-3-YL)P ROPAN-2-YL)-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE DERIVATIVES AS MPRO INHIBITORS FOR THE TREATMENT OF CORONAVIRUS INFECTIONS Takeda Pharmaceutical Company Limited (JP) 2025-07-23 EP disclosed
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2025-03-20 US disclosed
US-12220401-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY, INC. (US) 2025-02-11 US disclosed
US-11999734-B2 Compounds and compositions for the treatment of cystic fibrosis FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2024-06-04 US disclosed
US-5897940-A Ink jet transparencies XEROX CORPORATION (US) 1999-04-27 US disclosed
US-5824699-A COMPOUNDS FOR TREATMENT OF ARTHRITIS, COLORECTAL CANCER AND ALZHEIMER'S DISEASE AMERICAN HOME PRODUCTS CORPORATION (US) 1998-10-20 US disclosed
US-5776967-A ANTIINFLAMMATORY AGENTS; THERAPY FOR ARTHRITIC DISORDERS, COLORECTAL CANCER AND ALZHEIMER'S DISEASE AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-07 US disclosed
WO-1998004527-A1 PYRANOINDOLE AND CARBAZOLE INHIBITORS OF COX-2 AMERICAN HOME PRODUCTS CORPORATION (US) 1998-02-05 WO disclosed
EP-0682673-A4 POROMERIC MATERIAL HAVING UNIFORMLY DISTRIBUTED ELECTRETS. BUDINGER WILLIAM D (US) 1996-02-21 EP disclosed
EP-0682673-A1 POROMERIC MATERIAL HAVING UNIFORMLY DISTRIBUTED ELECTRETS Budinger, William D (US) 1995-11-22 EP disclosed
US-5384337-A Poromeric material having uniformly distributed electrets for maintaining an electrostatic charge BUDINGER WILLIAM D (US) 1995-01-24 US disclosed
WO-1994018242-A1 POROMERIC MATERIAL HAVING UNIFORMLY DISTRIBUTED ELECTRETS BUDINGER WILLIAM D (US) 1994-08-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132147-A1 BAX INHIBITORS AND USES THEREOF BAX, BCL2, BAK1 ALDH1A1 4585/4885CA9 1358/4885CA3 201/4885
US-12220401-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK ALDH1A1 4454/4885CA9 3397/4885CA3 4462/4885
US-11999734-B2 Compounds and compositions for the treatment of cystic fibrosis CFTR, ABCB11, ABCC5 ALDH1A1 2608/4885CA9 1348/4885CA3 3011/4885
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK ALDH1A1 4454/4885CA9 3397/4885CA3 4462/4885
US-12497394-B2 Fused-cyclic pyrazolone formamide compound and preparation method therefor, pharmaceutical composition and use thereof AXL, WEE1, FLT3 ALDH1A1 3585/4885CA9 2957/4885CA3 4391/4885
US-12479857-B2 Bax inhibitors and uses thereof BAX, TMBIM6, BCL2 ALDH1A1 4296/4885CA9 3830/4885CA3 2722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.