Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243560 | 0.84 | GPR119 (0.79) | GPR119PIK3CD | |
| SCHEMBL386450 | 0.80 | GPR119 (1.00) | GPR119 | |
| SCHEMBL388346 | 0.80 | GPR119 (1.00) | GPR119 | |
| SCHEMBL16151700 | 0.76 | GPR119 (0.66) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL12506101 | 0.75 | GPR119 (0.45) | GPR119PIK3CD | |
| SCHEMBL1243283 | 0.74 | PTGS2 (0.50) | GPR119PTGS2PTGS1 | |
| SCHEMBL1244926 | 0.73 | GPR119 (0.50) | GPR119PTGS2PTGS1 | |
| SCHEMBL12835604 | 0.69 | GPR119 (0.47) | GPR119 | |
| SCHEMBL4717235 | 0.68 | HRH1 (0.56) | GPR119PTGS2 | |
| SCHEMBL5050864 | 0.67 | GPR119 (0.44) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |