Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12435943 | 0.84 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9ATP53KMT2A | |
| SCHEMBL12435969 | 0.81 | MAPKAPK2 (0.43) | RPS6KA2SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL19151023 | 0.79 | ADORA3 (0.53) | HDAC1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL12436031 | 0.77 | MAPK1 (0.57) | SMN1; SMN2NPC1RAB9ATP53KMT2A | |
| SCHEMBL12435962 | 0.75 | MAPT (0.49) | SMN1; SMN2NPC1RAB9ATP53KMT2A | |
| SCHEMBL12435909 | 0.75 | ATM (0.52) | SMN1; SMN2TP53KMT2AMAPTMAPK1 | |
| SCHEMBL12435951 | 0.74 | RXFP1 (0.60) | SMN1; SMN2NPC1RAB9ATP53KMT2A | |
| SCHEMBL12436030 | 0.74 | MEN1 (0.58) | HDAC1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL12435965 | 0.73 | KMT2A (0.56) | SMN1; SMN2NPC1RAB9ATP53KMT2A | |
| SCHEMBL12435991 | 0.73 | MAPT (0.47) | SMN1; SMN2NPC1RAB9ATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Academy of Medical Science (CN) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | CUL3, APOBEC3G, BRPF3 | HDAC1 1555/4885RPS6KA2 3311/4885SMN1; SMN2 4598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.