Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14434778 | 0.78 | APP (0.39) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL29653731 | 0.76 | APP (0.34) | MEN1MAPTKMT2AMAPK1LMNA | |
| SCHEMBL13698927 | 0.76 | APP (0.34) | MEN1MAPTKMT2AMAPK1LMNA | |
| SCHEMBL29012247 | 0.76 | APP (0.34) | MEN1MAPTKMT2AMAPK1LMNA | |
| SCHEMBL30139605 | 0.73 | HPGD (0.33) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| Bromide SCHEMBL1227486 | 0.73 | APP (0.41) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL30139606 | 0.73 | KDM4E (0.32) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL1226875 | 0.72 | APP (0.42) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL1226876 | 0.72 | APP (0.42) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL9812776 | 0.71 | RELA (0.45) | MEN1MAPTKMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459733-B1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-08 | — | — | EP | claimed |
| US-8535902-B2 | Peptidase substrates | bioMërieux, S.A. | 2013-09-17 | — | — | US | claimed |
| EP-2459733-A2 | NOVEL PEPTIDASE SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | claimed |
| US-20120129203-A1 | Novel Peptidase Substrates | bioMerieux, SA (FR) | 2012-05-24 | — | — | US | claimed |
| WO-2011012807-A2 | NOVEL PEPTIDASE SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | claimed |
| EP-2459733-B1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-08 | — | — | EP | disclosed |
| US-8535902-B2 | Peptidase substrates | bioMërieux, S.A. | 2013-09-17 | — | — | US | disclosed |
| EP-2459733-A2 | NOVEL PEPTIDASE SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | disclosed |
| US-20120129203-A1 | Novel Peptidase Substrates | bioMerieux, SA (FR) | 2012-05-24 | — | — | US | disclosed |
| WO-2011012807-A2 | NOVEL PEPTIDASE SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129203-A1 | Novel Peptidase Substrates | CTRL, CPB1, ANPEP | TAAR1 790/4885XIAP 3952/4885LTA4H 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.