Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001485 | 0.79 | MAPT (0.72) | MAPTMEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL6000138 | 0.76 | KMT2A (0.44) | MAPTMEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL12225772 | 0.67 | RXRA (0.57) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL10104745 | 0.67 | ALDH1A1 (0.53) | MAPTKMT2AMAOBALDH1A1KDM4E | |
| SCHEMBL23309025 | 0.66 | FFAR1 (0.49) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2623677 | 0.65 | NQO1 (0.52) | ALDH1A1KDM4EHPGDSMN1; SMN2TP53 | |
| SCHEMBL12436603 | 0.64 | KMT2A (0.46) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2129509 | 0.64 | MAOA (0.66) | MAPTMEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL6000106 | 0.64 | MAPT (0.77) | MAPTMEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL15503719 | 0.63 | MAPT (1.00) | MAPTMEN1KMT2AMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011094708-A2 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATIING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | DANA-FARBER CANCER INSTITUTE, INC (US) | 2011-08-04 | — | — | WO | disclosed |