SCHEMBL12437264

SCHEMBL12437264

CCc1ccc(C=O)cc1N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.42
ALDH1A3 P47895 4/20 0.42
ALDH3A1 P30838 4/20 0.42
TSHR P16473 1/20 0.41
KDM4E B2RXH2 1/20 0.40
PTGS2 P35354 1/20 0.40
RAB9A P51151 1/20 0.40
TDP1 Q9NUW8 2/20 0.39
HSD17B10 Q99714 1/20 0.39
CYP2A6 P11509 3/20 0.39
FDPS P14324 1/20 0.39
HPGD P15428 2/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
PTGER4 P35408 1/20 0.38
AOX1 Q06278 1/20 0.37
TRIM24 O15164 1/20 0.37
ALDH5A1 P51649 1/20 0.37
ABAT P80404 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9472049 0.85 ALDH1A1 (0.44) ALDH1A1ALDH1A3ALDH3A1TSHRKDM4E
SCHEMBL13319265 0.83 KDM4E (0.42) ALDH1A1ALDH1A3TSHRKDM4EPTGS2
SCHEMBL5225614 0.83 TYR (0.38) ALDH1A1ALDH1A3TSHRKDM4EPTGS2
SCHEMBL27756844 0.83 ALDH1A1 (0.43) ALDH1A1TSHRRAB9ATDP1CYP2A6
SCHEMBL606640 0.82 ALDH1A1 (0.45) ALDH1A1ALDH1A3ALDH3A1TSHRKDM4E
SCHEMBL7124340 0.78 ALDH1A1 (0.46) ALDH1A1ALDH1A3ALDH3A1TSHRKDM4E
SCHEMBL28716561 0.78 ALDH1A1 (0.39) ALDH1A1ALDH1A3ALDH3A1TSHRKDM4E
SCHEMBL2724314 0.77 ALDH1A1 (0.41) ALDH1A1ALDH1A3ALDH3A1TSHRKDM4E
SCHEMBL3431177 0.77 KDM4E (0.59) ALDH1A1ALDH1A3ALDH3A1TSHRKDM4E
SCHEMBL2909366 0.77 ALDH1A3 (0.58) ALDH1A1ALDH1A3ALDH3A1TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2354118-A1 Process for the preparation of combretastatine Aventis Pharma S.A. (FR) 2011-08-10 EP disclosed