Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274871 | 0.84 | ALDH1A1 (0.61) | ERN1KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL12437574 | 0.81 | KMT2A (0.46) | KMT2ALMNAGAAALDH1A1CYP1A2 | |
| SCHEMBL12437522 | 0.81 | PDE7A (0.56) | ERN1KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL275721 | 0.80 | TBXA2R (0.42) | ERN1KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL274272 | 0.78 | ERN1 (0.41) | ERN1KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL276700 | 0.77 | ERN1 (0.47) | ERN1KMT2ALMNAALDH1A1CYP1A2 | |
| SCHEMBL276088 | 0.75 | NPSR1 (0.45) | ERN1KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL5784796 | 0.73 | LMNA (0.72) | KMT2ALMNAGAAALDH1A1CYP1A2 | |
| SCHEMBL31402282 | 0.72 | ALDH1A1 (0.55) | ERN1LMNAALDH1A1TDP1CYP3A4 | |
| SCHEMBL3733145 | 0.72 | ALDH1A1 (0.55) | ERN1LMNAALDH1A1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |