Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237160 | 0.78 | MAPT (0.50) | MAPTALDH1A1POLBSMN1; SMN2USP2 | |
| SCHEMBL1811683 | 0.73 | KMT2A (0.54) | MAPTALDH1A1SMN1; SMN2USP2PPARA | |
| SCHEMBL1811163 | 0.72 | PPARA (0.67) | MAPTALDH1A1POLBPPARAPPARD | |
| SCHEMBL15912487 | 0.72 | KMT2A (0.48) | MAPTALDH1A1SMN1; SMN2PPARAPPARD | |
| SCHEMBL15718379 | 0.71 | MGLL (0.42) | MAPTALDH1A1POLBSMN1; SMN2PPARA | |
| SCHEMBL3573347 | 0.71 | PPARA (0.50) | MAPTALDH1A1SMN1; SMN2USP2PPARA | |
| SCHEMBL3233909 | 0.71 | KMT2A (0.47) | MAPTSMN1; SMN2PPARAPPARDMEN1 | |
| SCHEMBL21198695 | 0.69 | OGG1 (0.55) | ALDH1A1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1154731 | 0.69 | PPARA (0.71) | MAPTALDH1A1SMN1; SMN2PPARAPPARD | |
| SCHEMBL28574004 | 0.69 | EPHX2 (0.52) | MAPTALDH1A1POLBSMN1; SMN2PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |