Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530922 | 0.83 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL17119223 | 0.80 | ALDH1A1 (0.32) | MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3198101 | 0.79 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL24394699 | 0.75 | MAPT (0.39) | MAPTKMT2ALMNAPOLBGAA | |
| SCHEMBL9527558 | 0.74 | MAPT (0.45) | MAPTALDH1A1KMT2A | |
| SCHEMBL9063186 | 0.72 | MAPT (0.43) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL31265110 | 0.72 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL9526575 | 0.70 | POLB (0.34) | MAPTALDH1A1KMT2APOLBGAA | |
| SCHEMBL22260783 | 0.70 | ALDH1A1 (0.45) | ALDH1A1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL11849287 | 0.70 | KDM4E (0.34) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357181-A1 | 2,4-Diaminopyrimidines as inhibitors of cell cycle kinases | Boehringer Ingelheim International GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2007132010-A1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | WO | disclosed |