SCHEMBL12438744

SCHEMBL12438744

COc1ccc(C2(c3ccc(OC(C)=O)c(Cl)c3)CCCCC2)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.46
PPARA Q07869 1/20 0.42
TSHR P16473 2/20 0.41
CASP1 P29466 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
HPGD P15428 3/20 0.39
ALDH1A1 P00352 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TP53 P04637 1/20 0.39
PKM P14618 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
NR3C1 P04150 1/20 0.38
TNFSF11 O14788 1/20 0.38
GAA P10253 1/20 0.38
MAPK1 P28482 1/20 0.37
JUN P05412 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL804639 0.83 PPARA (0.54) LMNAPPARATSHRCASP1MEN1
SCHEMBL26009186 0.83 PPARA (0.54) LMNAPPARATSHRCASP1MEN1
SCHEMBL26009188 0.83 PPARA (0.54) LMNAPPARATSHRCASP1MEN1
SCHEMBL17084644 0.81 PPARA (0.52) LMNAPPARATSHRCASP1MEN1
SCHEMBL14175568 0.81 PPARA (0.46) LMNAPPARATSHRCASP1MEN1
SCHEMBL14339221 0.80 LMNA (0.37) LMNAPPARATSHRCASP1MEN1
SCHEMBL13163884 0.79 LMNA (0.43) LMNAPPARATSHRCASP1MEN1
SCHEMBL12438743 0.78 BACE1 (0.43) LMNAPPARATSHR
SCHEMBL12438745 0.78 PTGDR2 (0.43) LMNAPPARATSHRCASP1MEN1
SCHEMBL13054841 0.77 LMNA (0.38) LMNAPPARACASP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8396399-B2 Toner bearing member, developing device, image forming apparatus, and image forming method RICOH COMPANY, LTD. (JP) 2013-03-12 US disclosed
US-8369755-B2 Developing device and image forming apparatus using the developing device RICOH COMPANY, LTD. (JP) 2013-02-05 US disclosed
US-20110176835-A1 TONER BEARING MEMBER, DEVELOPMENT DEVICE, AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD (JP) 2011-07-21 US disclosed
US-20100329748-A1 DEVELOPING DEVICE AND IMAGE FORMING APPARATUS USING THE DEVELOPING DEVICE RICOH COMPANY, LTD. (JP) 2010-12-30 US disclosed
US-20100303509-A1 Toner Bearing Member, Developing Device, Image Forming Apparatus, And Image Forming Method RICOH COMPANY, LTD. (JP) 2010-12-02 US disclosed