SCHEMBL12438754

SCHEMBL12438754

C=C[Si](C)(C)c1ccc(NC(=O)F)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.47
NR1H3 Q13133 1/20 0.47
TGM2 P21980 7/20 0.40
LMNA P02545 2/20 0.36
F13A1 P00488 1/20 0.36
TGM1 P22735 1/20 0.36
TGM3 Q08188 1/20 0.36
EPHX2 P34913 1/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 4/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
THRB P10828 2/20 0.33
HTT P42858 2/20 0.33
ALDH1A1 P00352 1/20 0.33
NPC1 O15118 1/20 0.33
GMNN O75496 1/20 0.33
TP53 P04637 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
HTR1A P08908 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6765203 0.81 TGM2 (0.42) NR1H2NR1H3TGM2LMNAMAPT
SCHEMBL16687935 0.79 NR1H2 (0.44) NR1H2NR1H3TGM2LMNAEPHX2
SCHEMBL10324208 0.76 PSMB8 (0.49) NR1H2NR1H3
SCHEMBL678612 0.74 NR1H2 (0.59) NR1H2NR1H3
SCHEMBL18806248 0.71 TGM2 (0.42) TGM2MAPTSMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL14208590 0.70 NR1H2 (0.42) NR1H2NR1H3SMN1; SMN2L3MBTL1THRB
SCHEMBL11355232 0.69 NR1H2 (0.47) NR1H2NR1H3THRBALDH1A1
SCHEMBL11351398 0.69 HPGD (0.59) NR1H2NR1H3SMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL11790956 0.69 TDP1 (0.64) TGM2MAPTSMN1; SMN2HTTNPC1
SCHEMBL2558126 0.69 NR1H2 (0.55) NR1H2NR1H3LMNAMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9023927-B2 Adhesive composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 2015-05-05 US disclosed
US-8440777-B2 Addition-cure fluoropolyether adhesive composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 2013-05-14 US disclosed
US-20110178263-A1 ADDITION-CURE FLUOROPOLYETHER ADHESIVE COMPOSITION SHIN-ETSU CHEMICAL CO., LTD. (JP) 2011-07-21 US disclosed