Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12439398 | 0.92 | IGF1R (0.53) | IGF1RJAK2JAK3TNK2 | |
| SCHEMBL14320040 | 0.82 | IGF1R (0.49) | IGF1RJAK2JAK3NAPEPLDTNK2 | |
| SCHEMBL1793212 | 0.81 | IGF1R (0.78) | IGF1R | |
| SCHEMBL14161970 | 0.80 | IGF1R (0.48) | IGF1R | |
| SCHEMBL12439829 | 0.78 | IGF1R (0.52) | IGF1RJAK2JAK3 | |
| SCHEMBL14320000 | 0.77 | IGF1R (0.52) | IGF1RJAK2JAK3NAPEPLDHTT | |
| SCHEMBL12652961 | 0.73 | IGF1R (0.66) | IGF1R | |
| SCHEMBL1787532 | 0.73 | IGF1R (0.78) | IGF1R | |
| SCHEMBL12439783 | 0.73 | IGF1R (0.51) | IGF1R | |
| SCHEMBL14161981 | 0.71 | IGF1R (0.53) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124161-A1 | METHODS OF TREATING CANCER USING PYRIDOPYRIMIDINONE INHIBITORS OF PI3K ALPHA | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |