Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12440207 | 0.76 | CRHR1 (0.50) | CRHR1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL24757773 | 0.76 | P2RY14 (0.48) | CRHR1KCNJ6KCNJ5KCNJ3RAB9A | |
| SCHEMBL31327098 | 0.76 | P2RY14 (0.40) | CRHR1KCNJ6KCNJ5KCNJ3RAB9A | |
| SCHEMBL12440718 | 0.75 | CRHR1 (0.46) | CRHR1KCNJ6KCNJ5KCNJ3RAB9A | |
| SCHEMBL16347382 | 0.74 | KDM4E (0.43) | KCNJ6KCNJ5KCNJ3KDM4E | |
| SCHEMBL25745815 | 0.73 | CNR1 (0.47) | CRHR1KCNJ6KCNJ5KCNJ3RAB9A | |
| SCHEMBL22667106 | 0.73 | CRHR1 (0.50) | CRHR1KCNJ6KCNJ5KCNJ3RAB9A | |
| SCHEMBL24757774 | 0.73 | LMNA (0.45) | CRHR1KCNJ6KCNJ5KCNJ3RAB9A | |
| SCHEMBL15746137 | 0.72 | GAA (0.42) | CRHR1MAPTNPSR1LMNAPKM | |
| SCHEMBL16168603 | 0.72 | RAB9A (0.56) | KCNJ6KCNJ5KCNJ3RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011095450-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-11 | — | — | WO | disclosed |