SCHEMBL12440765

SCHEMBL12440765

CBCc1ccc(C(=O)Nc2cc(C)c(NC(=O)c3ccc(CC)cc3)cc2Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
SMN1; SMN2 Q16637 3/20 0.54
EGFR P00533 1/20 0.49
POLB P06746 2/20 0.48
KMT2A Q03164 2/20 0.48
MAPT P10636 7/20 0.46
GAA P10253 3/20 0.46
AGTR1 P30556 1/20 0.46
CYP1A2 P05177 2/20 0.43
THRB P10828 1/20 0.42
LMNA P02545 4/20 0.42
MAPK1 P28482 1/20 0.42
NLRP1 Q9C000 1/20 0.42
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41
TAS1R2 Q8TE23 1/20 0.41
ALDH1A1 P00352 1/20 0.41
PLK1 P53350 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12440757 0.94 NPC1 (0.59) NPC1RAB9ASMN1; SMN2EGFRPOLB
SCHEMBL12440778 0.93 NPC1 (0.49) NPC1RAB9ASMN1; SMN2EGFRPOLB
SCHEMBL12440808 0.83 EGFR (0.48) NPC1RAB9ASMN1; SMN2EGFRMAPT
SCHEMBL12440769 0.82 NPC1 (0.56) NPC1RAB9AEGFRPOLBKMT2A
SCHEMBL18177271 0.81 NPC1 (0.49) NPC1RAB9ASMN1; SMN2EGFRPOLB
SCHEMBL2022473 0.81 KMT2A (0.56) NPC1RAB9ASMN1; SMN2EGFRPOLB
SCHEMBL12440836 0.78 NPC1 (0.48) NPC1RAB9ASMN1; SMN2EGFRPOLB
SCHEMBL12440811 0.78 PLK1 (0.45) NPC1RAB9ASMN1; SMN2EGFRMAPT
SCHEMBL12440754 0.77 PLK1 (0.50) NPC1RAB9ASMN1; SMN2POLBMAPT
SCHEMBL12440780 0.76 RAB9A (0.54) NPC1RAB9ASMN1; SMN2KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8519040-B2 Ionic organic compound, production method thereof, hydrogelling agent composed of the ionic organic compound, hydrogel containing same, methanol gelling agent, methanol gel containing same, and carbon nanotube dispersant NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2013-08-27 US disclosed
US-20110178218-A1 IONIC ORGANIC COMPOUND, PRODUCTION METHOD THEREOF, HYDROGELLING AGENT COMPOSED OF THE IONIC ORGANIC COMPOUND, HYDROGEL CONTAINING SAME, METHANOL GELLING AGENT, METHANOL GEL CONTAINING SAME, AND CARBON NANOTUBE DISPERSANT National Institute of Avanced Industrial Science and Technology (JP) 2011-07-21 US disclosed