SCHEMBL12440778

SCHEMBL12440778

CBCc1ccc(C(=O)Nc2cc(C)c(NC(=O)c3ccc(CC)cc3)cc2C)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.49
EGFR P00533 1/20 0.49
POLB P06746 1/20 0.48
KMT2A Q03164 1/20 0.48
PLK1 P53350 1/20 0.47
RAB9A P51151 5/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
NR1H4 Q96RI1 2/20 0.45
MAPT P10636 2/20 0.44
PKM P14618 1/20 0.44
P2RY14 Q15391 1/20 0.44
ALDH1A1 P00352 2/20 0.44
ITK Q08881 1/20 0.44
HDAC3 O15379 1/20 0.43
NCOR1 O75376 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC2 Q92769 1/20 0.43
GAA P10253 1/20 0.43
AGTR1 P30556 1/20 0.43
DEGS1 O15121 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12440765 0.93 NPC1 (0.54) NPC1EGFRPOLBKMT2APLK1
SCHEMBL12440808 0.90 EGFR (0.48) NPC1EGFRPLK1RAB9ASMN1; SMN2
SCHEMBL12440769 0.89 NPC1 (0.56) NPC1EGFRPOLBKMT2ARAB9A
SCHEMBL12440757 0.85 NPC1 (0.59) NPC1EGFRPOLBKMT2APLK1
SCHEMBL12440811 0.84 PLK1 (0.45) NPC1EGFRPLK1RAB9ASMN1; SMN2
SCHEMBL12440754 0.83 PLK1 (0.50) NPC1POLBPLK1RAB9ASMN1; SMN2
SCHEMBL12440780 0.82 RAB9A (0.54) NPC1KMT2APLK1RAB9ASMN1; SMN2
SCHEMBL12440796 0.82 TAOK1 (0.51) NPC1KMT2APLK1RAB9ASMN1; SMN2
SCHEMBL12440789 0.79 NR1H4 (0.52) NPC1KMT2APLK1RAB9ASMN1; SMN2
SCHEMBL12440794 0.79 PLK1 (0.53) NPC1KMT2APLK1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8519040-B2 Ionic organic compound, production method thereof, hydrogelling agent composed of the ionic organic compound, hydrogel containing same, methanol gelling agent, methanol gel containing same, and carbon nanotube dispersant NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2013-08-27 US disclosed
US-20110178218-A1 IONIC ORGANIC COMPOUND, PRODUCTION METHOD THEREOF, HYDROGELLING AGENT COMPOSED OF THE IONIC ORGANIC COMPOUND, HYDROGEL CONTAINING SAME, METHANOL GELLING AGENT, METHANOL GEL CONTAINING SAME, AND CARBON NANOTUBE DISPERSANT National Institute of Avanced Industrial Science and Technology (JP) 2011-07-21 US disclosed