Doqualast

Doqualast

SCHEMBL124450

O=C(O)c1ccc2nc3ccccn3c(=O)c2c1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.63
ALDH1A1 P00352 6/20 0.63
GLA P06280 5/20 0.63
GAA P10253 5/20 0.63
SMN1; SMN2 Q16637 4/20 0.63
ATM Q13315 1/20 0.56
RXFP1 Q9HBX9 1/20 0.56
ALPG P10696 1/20 0.53
AKR1B1 P15121 1/20 0.50
TP53 P04637 2/20 0.46
PTGS1 P23219 1/20 0.46
PTGS2 P35354 1/20 0.46
HPGD P15428 5/20 0.45
KMT2A Q03164 2/20 0.45
MAPT P10636 1/20 0.45
HSD17B10 Q99714 4/20 0.45
CASP1 P29466 2/20 0.45
CASP7 P55210 2/20 0.45
LMNA P02545 2/20 0.44
TOP2A P11388 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6313080 0.82 KDM4E (0.59) KDM4EALDH1A1GLAGAASMN1; SMN2
SCHEMBL11549158 0.81 KDM4E (0.74) KDM4EALDH1A1GLAGAASMN1; SMN2
SCHEMBL6311463 0.79 KDM4E (0.55) KDM4EALDH1A1GLAGAASMN1; SMN2
SCHEMBL28675231 0.79 KDM4E (0.67) KDM4EALDH1A1GLAGAASMN1; SMN2
SCHEMBL28355634 0.79 KDM4E (0.67) KDM4EALDH1A1GLAGAASMN1; SMN2
SCHEMBL28659594 0.79 KDM4E (0.67) KDM4EALDH1A1GLAGAASMN1; SMN2
SCHEMBL13256676 0.79 KDM4E (0.67) KDM4EALDH1A1GLAGAASMN1; SMN2
SCHEMBL30792513 0.79 KDM4E (0.67) KDM4EALDH1A1GLAGAASMN1; SMN2
SCHEMBL11240930 0.78 KDM4E (0.60) KDM4EALDH1A1GLAGAASMN1; SMN2
Hydrochloric Acid SCHEMBL11265359 0.78 KDM4E (0.65) KDM4EALDH1A1GLAGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-4332802-A 11-Oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid and salts thereof, antiallergic compositions containing it and methods of suppressing allergic reactions with it BOEHRINGER INGELHEIM KG (DE) 1982-06-01 US claimed
US-20250197401-A1 PURINONE DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2025-06-19 US disclosed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 EP disclosed
US-20240317751-A1 PURINONE DERIVATIVE HYDROCHLORIDE ONO PHARMACEUTICAL CO., LTD. (JP) 2024-09-26 US disclosed
US-20240083899-A1 PURINONE DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2024-03-14 US disclosed
US-11897885-B2 Purinone derivative hydrochloride ONO PHARMACEUTICAL CO., LTD. (JP) 2024-02-13 US disclosed
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 US disclosed
EP-0681833-A2 Nasally administrable compositions DOTT RESEARCH LABORATORY (JP) 1995-11-15 EP disclosed
US-4348396-A Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them HOFFMANN-LA ROCHE INC. (US) 1982-09-07 US disclosed
US-4332802-A 11-Oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid and salts thereof, antiallergic compositions containing it and methods of suppressing allergic reactions with it BOEHRINGER INGELHEIM KG (DE) 1982-06-01 US disclosed
US-4332802-A 11-Oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid and salts thereof, antiallergic compositions containing it and methods of suppressing allergic reactions with it BOEHRINGER INGELHEIM KG (DE) 1982-06-01 US disclosed
US-4332802-A 11-Oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid and salts thereof, antiallergic compositions containing it and methods of suppressing allergic reactions with it BOEHRINGER INGELHEIM KG (DE) 1982-06-01 US disclosed
US-4241068-A ANTIALLERGENS BOEHRINGER INGELHEIM GMBH (DE) 1980-12-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240317751-A1 PURINONE DERIVATIVE HYDROCHLORIDE BTK, P2RY1, P2RY13 KDM4E 352/4885ALDH1A1 2586/4885GLA 4764/4885
US-11897885-B2 Purinone derivative hydrochloride BTK, P2RY1, P2RY13 KDM4E 352/4885ALDH1A1 2586/4885GLA 4764/4885
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 KDM4E 3590/4885ALDH1A1 72/4885GLA 219/4885
US-20250197401-A1 PURINONE DERIVATIVE BTK, KIT, SYK KDM4E 693/4885ALDH1A1 492/4885GLA 3756/4885
US-20240083899-A1 PURINONE DERIVATIVE BTK, KIT, SYK KDM4E 693/4885ALDH1A1 492/4885GLA 3756/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.