Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 7/20 | 0.39 |
| ▸ | BRD2 | P25440 | 3/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2872731 | 0.84 | L3MBTL1 (0.55) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL2872727 | 0.84 | ALDH1A1 (0.56) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL512933 | 0.84 | L3MBTL1 (0.58) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL13617499 | 0.81 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL14996219 | 0.81 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL2704689 | 0.76 | NPC1 (0.50) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL12966700 | 0.70 | CASP3 (0.45) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL15013287 | 0.70 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL21872264 | 0.69 | — | — | |
| SCHEMBL10053916 | 0.67 | MAPT (0.57) | L3MBTL1ALDH1A1LMNAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797048-B1 | HIV INHIBITING 5-CARBO- OR HETEROCYCLIC SUBSTITUTED PYRIMIDINES | TIBOTEC PHARM LTD (IE) | 2011-08-17 | — | — | EP | disclosed |
| US-7531548-B2 | HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines | TIBOTEC PHARMACEUTICALS LTD (IE) | 2009-05-12 | — | — | US | disclosed |
| US-7531548-B2 | HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines | TIBOTEC PHARMACEUTICALS LTD (IE) | 2009-05-12 | — | — | US | disclosed |
| US-20070208022-A1 | HIV INHIBITING 5-CARBO- OR HETEROCYCLYL SUBSTITUTED PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-09-06 | — | — | US | disclosed |
| US-20070208022-A1 | HIV INHIBITING 5-CARBO- OR HETEROCYCLYL SUBSTITUTED PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208022-A1 | HIV INHIBITING 5-CARBO- OR HETEROCYCLYL SUBSTITUTED PYRIMIDINES | CCNO, COX6C, CCR6 | L3MBTL1 58/4885ALDH1A1 3126/4885LMNA 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.