SCHEMBL12376992

SCHEMBL12376992

COc1ccc(C(C)(C)c2ccc(OC(=O)c3ccc(C(=O)Oc4ccc(C(C)(C)c5ccc(OC(=O)c6cccc(C(C)=O)c6)c(C)c5)cc4C)cc3)c(C)c2)cc1C

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.43
ALDH1A1 P00352 4/20 0.43
KMT2A Q03164 6/20 0.42
MEN1 O00255 3/20 0.42
TSHR P16473 2/20 0.42
KDM4E B2RXH2 1/20 0.42
HPGD P15428 1/20 0.42
HSD17B10 Q99714 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
LMNA P02545 2/20 0.40
CREBBP Q92793 1/20 0.40
USP2 O75604 1/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14007585 0.98 MAPT (0.43) MAPTALDH1A1KMT2AMEN1TSHR
SCHEMBL142010 0.98 KMT2A (0.43) MAPTALDH1A1KMT2AMEN1TSHR
SCHEMBL12404394 0.94 KMT2A (0.44) MAPTALDH1A1KMT2AMEN1TSHR
SCHEMBL19500466 0.94 MAPT (0.43) MAPTALDH1A1KMT2AMEN1TSHR
SCHEMBL17695181 0.93 KMT2A (0.42) MAPTALDH1A1KMT2AMEN1TSHR
SCHEMBL18680260 0.92 L3MBTL1 (0.47) MAPTALDH1A1KMT2AMEN1TSHR
SCHEMBL13657601 0.92 MAPT (0.53) MAPTALDH1A1KMT2AMEN1HPGD
SCHEMBL12345970 0.91 KMT2A (0.46) MAPTALDH1A1KMT2AMEN1GAA
SCHEMBL17447225 0.91 MAPT (0.41) MAPTALDH1A1KMT2AMEN1TSHR
SCHEMBL19500472 0.89 MAPT (0.44) MAPTALDH1A1KMT2AMEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10031431-B2 Electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2018-07-24 US disclosed
US-9874824-B2 Electrophotographic photoreceptor and image formation device MITSUBISHI CHEMICAL CORPORATION (JP) 2018-01-23 US disclosed
US-20180011412-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND IMAGE FORMING APPARATUS MITSUBISHI CHEMICAL CORPORATION (JP) 2018-01-11 US disclosed
US-20170371254-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND IMAGE FORMATION DEVICE MITSUBISHI CHEMICAL CORPORATION (JP) 2017-12-28 US disclosed
US-20170336724-A1 PHTHALOCYANINE CRYSTAL, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE AND IMAGE-FORMING DEVICE USING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2017-11-23 US disclosed
US-20170307989-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2017-10-26 US disclosed
US-9791791-B2 Electrophotographic photoreceptor, electrophotographic cartridge, image forming apparatus, and charge transport substance MITSUBISHI CHEMICAL CORPORATION (JP) 2017-10-17 US disclosed
US-20170261871-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR MITSUBISHI CHEMICAL CORPORATION (JP) 2017-09-14 US disclosed
US-9746816-B2 Image forming apparatus and electrophotographic cartridge MITSUBISHI CHEMICAL CORPORATION (JP) 2017-08-29 US disclosed
US-20170242353-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND COATING LIQUID FOR FORMING PHOTOSENSITIVE LAYER MITSUBISHI CHEMICAL CORPORATION (JP) 2017-08-24 US disclosed
US-9296899-B2 Phthalocyanine crystal, and electrophotographic photoreceptor, electrophotographic photoreceptor cartridge and image-forming device using the same MITSUBISHI CHEMICAL CORPORATION (JP) 2016-03-29 US disclosed
US-20160011528-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND IMAGE FORMATION DEVICE MITSUBISHI CHEMICAL CORPORATION (JP) 2016-01-14 US disclosed
US-20150205217-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE, IMAGE-FORMING APPARATUS, AND TRIARYLAMINE COMPOUND MITSUBISHI CHEMICAL CORPORATION (JP) 2015-07-23 US disclosed
US-20150168855-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE, AND IMAGE FORMING APPARATUS MITSUBISHI CHEMICAL CORPORATION (JP) 2015-06-18 US disclosed
US-8846282-B2 Phthalocyanine crystal, and electrophotographic photoreceptor, electrophotographic photoreceptor cartridge and image-forming device using the same MITSUBISHI CHEMICAL CORPORATION (JP) 2014-09-30 US disclosed
US-8663882-B2 Electrophotographic photosensitive body, image-forming device using same and cartridge MITSUBISHI CHEMICAL CORPORATION (JP) 2014-03-04 US disclosed
US-20120257907-A1 PHTHALOCYANINE CRYSTAL, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE AND IMAGE-FORMING DEVICE USING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2012-10-11 US disclosed
US-20110206411-A1 IMAGE FORMING APPARATUS AND ELECTROPHOTOGRAPHIC CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2011-08-25 US disclosed
US-20100232830-A1 PHTHALOCYANINE CRYSTAL, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE AND IMAGE-FORMING DEVICE USING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2010-09-16 US disclosed
US-20100150608-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE BODY, IMAGE-FORMING DEVICE USING SAME AND CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2010-06-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150205217-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE, IMAGE-FORMING APPARATUS, AND TRIARYLAMINE COMPOUND ALDH1A2, SLC18A2, SLC1A2 MAPT 3400/4885ALDH1A1 529/4885KMT2A 983/4885
US-20170261871-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR ALDH1A2, SLC9A2, SLC9A1 MAPT 2334/4885ALDH1A1 153/4885KMT2A 1298/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.