Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257632 | 0.83 | APP (0.41) | PDE3BPDE3AESR1ESR2TTR | |
| SCHEMBL19993198 | 0.80 | ESR1 (0.38) | ESR1ESR2TTRKDM4EMEN1 | |
| SCHEMBL14926554 | 0.79 | TTR (0.46) | PDE3BPDE3AESR1ESR2TTR | |
| SCHEMBL16104369 | 0.78 | LMNA (0.46) | PDE3BPDE3AESR1MEN1LMNA | |
| SCHEMBL19993062 | 0.78 | ESR1 (0.41) | PDE3BPDE3AESR1ESR2TTR | |
| SCHEMBL30665731 | 0.74 | ALOX5AP (0.45) | PDE3BPDE3AESR1ESR2TTR | |
| SCHEMBL29097482 | 0.74 | AHR (0.42) | PDE3BPDE3AKDM4E | |
| SCHEMBL12198995 | 0.74 | ALOX5AP (0.45) | PDE3BPDE3AESR1ESR2TTR | |
| SCHEMBL12357201 | 0.74 | CTSA (0.44) | PDE3BPDE3AMEN1ALDH1A1HPGD | |
| SCHEMBL2246071 | 0.74 | ESR1 (0.60) | ESR1ESR2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071669-B1 | MESOGENIC MEDIA AND LIQUID CRYSTAL DISPLAY DEVICE | MERCK PATENT GMBH (DE) | 2018-06-20 | — | — | EP | disclosed |
| EP-2729549-B1 | BIMESOGENIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-12-07 | — | — | EP | disclosed |
| WO-2013004333-A1 | BIMESOGENIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | WO | disclosed |
| EP-2360229-A1 | OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL ELEMENT | JNC Corporation (JP) | 2011-08-24 | — | — | EP | disclosed |