SCHEMBL14926554

SCHEMBL14926554

Fc1cc(F)cc(-c2ccc(F)cc2F)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.46
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 1/20 0.46
USP2 O75604 1/20 0.46
DHFR P00374 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
LMNA P02545 1/20 0.46
ALB P02768 1/20 0.46
HMGB1 P09429 1/20 0.46
HPGD P15428 1/20 0.46
CXCL12 P48061 1/20 0.46
KMT2A Q03164 1/20 0.46
HIF1A Q16665 1/20 0.46
SLC22A6 Q4U2R8 1/20 0.46
ACMSD Q8TDX5 1/20 0.46
HSD17B10 Q99714 1/20 0.46
TDP2 O95551 1/20 0.42
PDE3B Q13370 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20546438 0.85 TTR (0.41) TTRALDH1A1KDM4EMEN1USP2
SCHEMBL24017187 0.83 CNR1 (0.44) TTRALDH1A1KDM4EMEN1USP2
SCHEMBL9057929 0.82 ALDH1A1 (0.52) TTRALDH1A1KDM4EMEN1USP2
SCHEMBL14926547 0.81 CNR1 (0.49) TTRALDH1A1KDM4EMEN1USP2
SCHEMBL9135463 0.81 ALDH1A1 (0.52) TTRALDH1A1KDM4EMEN1USP2
SCHEMBL12357201 0.79 CTSA (0.44) ALDH1A1MEN1HPGDKMT2APDE3B
SCHEMBL30665731 0.79 ALOX5AP (0.45) TTRALDH1A1KDM4EMEN1USP2
SCHEMBL29097482 0.79 AHR (0.42) KDM4EPDE3BPDE3ACNR1KMO
SCHEMBL12198995 0.79 ALOX5AP (0.45) TTRALDH1A1KDM4EMEN1USP2
SCHEMBL12445903 0.79 PDE3B (0.39) TTRALDH1A1KDM4EMEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130114009-A1 OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-05-09 US disclosed