SCHEMBL1244728

SCHEMBL1244728

CC(C)(C)OC(=O)NCc1ccc(CC(=O)O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.56
NR1H4 Q96RI1 1/20 0.56
L3MBTL1 Q9Y468 2/20 0.53
HDAC1 Q13547 2/20 0.52
GAA P10253 1/20 0.51
NAMPT P43490 2/20 0.51
CA1 P00915 2/20 0.48
CA2 P00918 1/20 0.48
CA12 O43570 1/20 0.48
CA7 P43166 1/20 0.48
CA14 Q9ULX7 1/20 0.48
SDCBP O00560 1/20 0.46
SDC2 P34741 1/20 0.46
KDM4A O75164 1/20 0.45
MAPT P10636 2/20 0.45
TDP1 Q9NUW8 1/20 0.45
RECQL P46063 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
RORC P51449 1/20 0.44
CTSK P43235 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30736827 0.95 HDAC1 (0.58) EPHX2NR1H4L3MBTL1HDAC1GAA
SCHEMBL26130392 0.90 POLB (0.57) EPHX2NR1H4L3MBTL1HDAC1NAMPT
SCHEMBL3180689 0.90 L3MBTL1 (0.61) L3MBTL1HDAC1GAANAMPTCA1
SCHEMBL27426150 0.87 L3MBTL1 (0.53) EPHX2NR1H4L3MBTL1HDAC1GAA
SCHEMBL11521521 0.86 L3MBTL1 (0.55) L3MBTL1HDAC1GAANAMPTCA1
SCHEMBL8611284 0.86 L3MBTL1 (0.52) L3MBTL1HDAC1GAANAMPTCA1
SCHEMBL5209897 0.86 L3MBTL1 (0.52) L3MBTL1HDAC1GAANAMPTCA1
SCHEMBL5595267 0.85 L3MBTL1 (0.49) EPHX2NR1H4L3MBTL1HDAC1GAA
SCHEMBL2787151 0.85 GLS (0.58) HDAC1NAMPTCA1CA12CA7
SCHEMBL3838871 0.85 CA12 (0.63) L3MBTL1HDAC1NAMPTCA1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4563146-A1 FLAVIVIRUS INHIBITORS IRBM S.P.A. (IT) 2025-06-04 EP disclosed
US-20250170253-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2025-05-29 US disclosed
US-20240350643-A1 PROTEIN DEGRADATION AGENT SUZHOU KINTOR PHARMACEUTICALS, INC. (CN) 2024-10-24 US disclosed
CN-118290446-A Compound for inhibiting and degrading c-MYC and medical application thereof 西藏海思科制药有限公司 2024-07-05 CN disclosed
CN-118084881-A PROTAC small molecules, pharmaceutical composition and application thereof 南京正济医药研究有限公司 2024-05-28 CN disclosed
EP-4361141-A1 PROTEIN DEGRADATION AGENT Suzhou Kintor Pharmaceuticals, Inc. (CN) 2024-05-01 EP disclosed
CN-117545749-A Protein degradation agent 苏州开拓药业股份有限公司 2024-02-09 CN disclosed
CN-115504963-A C-Myc protein degradation agent 苏州开拓药业股份有限公司 2022-12-23 CN disclosed
US-20220265841-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE, INC. 2022-08-25 US disclosed
EP-3875082-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS Endocyte, Inc. (US) 2021-09-08 EP disclosed
EP-1216236-A1 TRYPTASE INHIBITORS Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2002-06-26 EP disclosed
WO-2002047762-A1 SERINE PROTEASE INHIBITORS TULARIK LIMITED (GB) 2002-06-20 WO disclosed
EP-1192135-A2 SERINE PROTEASE INHIBITORS ELI LILLY AND COMPANY (US) 2002-04-03 EP disclosed
WO-2001027096-A9 AMINOMETHYL-(HETERO)ARYL DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS PROTHERICS MOLECULAR DESIGN LT (GB) 2001-07-12 WO disclosed
WO-2001044226-A1 SERINE PROTEASE INHIBITORS TULARIK LIMITED (GB) 2001-06-21 WO disclosed
WO-2001027096-A1 AMINOMETHYL-(HETERO)ARYL DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS TULARIK LIMITED (GB) 2001-04-19 WO disclosed
WO-2001019809-A1 TRYPTASE INHIBITORS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2001-03-22 WO disclosed
WO-2000076970-A2 SERINE PROTEASE INHIBITORS ELI LILLY AND COMPANY (US) 2000-12-21 WO disclosed
WO-2000077027-A2 SERINE PROTEASE INHIBITORS TULARIK LIMITED (GB) 2000-12-21 WO disclosed
US-4159373-A 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins SMITHKLINE CORPORATION (US) 1979-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240350643-A1 PROTEIN DEGRADATION AGENT MYC, MYCBP, MYCBP2 EPHX2 4529/4885NR1H4 4290/4885L3MBTL1 1166/4885
US-20220265841-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 EPHX2 1280/4885NR1H4 203/4885L3MBTL1 986/4885
US-20250170253-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 EPHX2 1280/4885NR1H4 203/4885L3MBTL1 986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.