Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | USP2 | O75604 | 2/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.81 |
| ▸ | TP53 | P04637 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | HPGD | P15428 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.77 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.61 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.61 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.61 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.61 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.61 |
| ▸ | PTPRC | P08575 | 2/20 | 0.61 |
| ▸ | PTPRF | P10586 | 2/20 | 0.61 |
| ▸ | F3 | P13726 | 2/20 | 0.61 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sumaresinolic Acid SCHEMBL15382986 | 0.90 | CYP3A4 (1.00) | CYP3A4USP2TDP1KDM4EALDH1A1 | |
| Sumaresinolic Acid SCHEMBL12447712 | 0.90 | CYP3A4 (1.00) | CYP3A4USP2TDP1KDM4EALDH1A1 | |
| Sumaresinolic Acid SCHEMBL14029520 | 0.90 | CYP3A4 (1.00) | CYP3A4USP2TDP1KDM4EALDH1A1 | |
| SCHEMBL16509940 | 0.89 | PTPN1 (0.72) | CYP3A4USP2TDP1KDM4EALDH1A1 | |
| Methyl Oleanolate SCHEMBL2871108 | 0.87 | PTPN1 (1.00) | USP2PTPN1POLBPTPN2PSMB11 | |
| Methyl Oleanolate SCHEMBL15714066 | 0.87 | PTPN1 (1.00) | USP2PTPN1POLBPTPN2PSMB11 | |
| Methyl Oleanolate SCHEMBL31607219 | 0.87 | PTPN1 (1.00) | USP2PTPN1POLBPTPN2PSMB11 | |
| Methyl Oleanolate SCHEMBL18688363 | 0.87 | PTPN1 (1.00) | USP2PTPN1POLBPTPN2PSMB11 | |
| Methyl Oleanolate SCHEMBL21150623 | 0.87 | PTPN1 (1.00) | USP2PTPN1POLBPTPN2PSMB11 | |
| Methyl Oleanolate SCHEMBL18688663 | 0.87 | PTPN1 (1.00) | USP2PTPN1POLBPTPN2PSMB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338618-B2 | Antioxidant inflammation modulators: novel derivatives of oleanolic acid | REATA PHARMACEUTICALS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338618-B2 | Antioxidant inflammation modulators: novel derivatives of oleanolic acid | REATA PHARMACEUTICALS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20120238767-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | REATA PHARMACEUTICALS, INC. | 2012-09-20 | — | — | US | disclosed |
| US-20120238767-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | REATA PHARMACEUTICALS, INC. | 2012-09-20 | — | — | US | disclosed |
| US-8071632-B2 | Antioxidant inflammation modulators: novel derivatives of oleanolic acid | REATA PHARMACEUTICALS, INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071632-B2 | Antioxidant inflammation modulators: novel derivatives of oleanolic acid | REATA PHARMACEUTICALS, INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20100048911-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | REATA PHARMACEUTICALS, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100048911-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | REATA PHARMACEUTICALS, INC. | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238767-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | ALOX12, NFE2L2, HMOX1 | CYP3A4 1940/4885USP2 2219/4885TDP1 3036/4885 |
| US-20100048911-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | ALOX12, NFE2L2, HMOX1 | CYP3A4 1940/4885USP2 2219/4885TDP1 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.