Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12449583 | 0.88 | MCHR1 (0.55) | LTA4HMCHR1TEAD1KCNH2SIGMAR1 | |
| SCHEMBL12449546 | 0.84 | TEAD1 (0.54) | LTA4HMCHR1TEAD1KCNH2SIGMAR1 | |
| SCHEMBL12449570 | 0.81 | BRD4 (0.46) | LTA4HS1PR1S1PR5SIGMAR1KDM4E | |
| SCHEMBL798068 | 0.81 | HRH3 (0.58) | S1PR1S1PR4S1PR5TEAD1S1PR3 | |
| SCHEMBL12311 | 0.81 | S1PR1 (0.51) | LTA4HS1PR1S1PR5SIGMAR1ALDH1A1 | |
| SCHEMBL12449595 | 0.79 | S1PR4 (0.48) | S1PR1S1PR4S1PR5TEAD1S1PR3 | |
| SCHEMBL22731730 | 0.79 | SIGMAR1 (0.50) | S1PR1S1PR4S1PR5TEAD1S1PR3 | |
| SCHEMBL28369901 | 0.79 | LTA4H (0.50) | LTA4HS1PR1S1PR5MCHR1KCNH2 | |
| SCHEMBL15942967 | 0.79 | S1PR1 (0.51) | S1PR1S1PR4S1PR5TEAD1S1PR3 | |
| SCHEMBL18491559 | 0.79 | LTA4H (0.50) | LTA4HMCHR1KCNH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | PI4KB, MTOR, PI4KA | LTA4H 2402/4885S1PR1 267/4885S1PR4 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.