Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.49 |
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797735 | 0.86 | SIGMAR1 (0.60) | HRH3HRH4SIGMAR1KCNH2HSD11B1 | |
| SCHEMBL11099523 | 0.84 | SIGMAR1 (0.68) | HRH3HRH4SIGMAR1S1PR4S1PR1 | |
| SCHEMBL12198326 | 0.84 | KDM4E (0.59) | HRH3HRH4TEAD1KDM4EALDH1A1 | |
| SCHEMBL15942967 | 0.84 | S1PR1 (0.51) | HRH3HRH4SIGMAR1S1PR4S1PR1 | |
| SCHEMBL12449595 | 0.84 | S1PR4 (0.48) | HRH3HRH4SIGMAR1S1PR4S1PR1 | |
| SCHEMBL22731730 | 0.84 | SIGMAR1 (0.50) | HRH3HRH4SIGMAR1S1PR4S1PR1 | |
| SCHEMBL798027 | 0.82 | HRH3 (0.69) | HRH3SIGMAR1KCNH2TEAD1LMNA | |
| SCHEMBL31612506 | 0.81 | SIGMAR1 (0.51) | SIGMAR1S1PR4S1PR1S1PR5KCNH2 | |
| SCHEMBL12449596 | 0.81 | LTA4H (0.48) | SIGMAR1S1PR4S1PR1S1PR5KCNH2 | |
| SCHEMBL6047987 | 0.80 | KCNH2 (0.50) | SIGMAR1S1PR4S1PR1S1PR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159491-A1 | Antimicrobial Compounds and Methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-25 | — | — | US | disclosed |
| US-8802663-B2 | Pyrazole oxadiazole derivatives as S1P1 agonists | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | disclosed |
| US-8530462-B2 | Indole modulators of S1P receptors | ALLERGAN, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | ALLERGAN, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120071460-A1 | PYRAZOLE OXADIAZOLE DERIVATIVES AS S1P1 AGONISTS | MERCK SERONO SA (CH) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129829-A1 | NOVEL INDOLE MODULATORS OF S1P RECEPTORS | S1PR1, S1PR3, S1PR2 | HRH3 295/4885HRH4 334/4885SIGMAR1 179/4885 |
| US-20230159491-A1 | Antimicrobial Compounds and Methods | MPO, NISCH, RPN2 | HRH3 2165/4885HRH4 2119/4885SIGMAR1 1380/4885 |
| US-20120071460-A1 | PYRAZOLE OXADIAZOLE DERIVATIVES AS S1P1 AGONISTS | S1PR1, S1PR3, S1PR2 | HRH3 196/4885HRH4 252/4885SIGMAR1 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.