SCHEMBL1244973

SCHEMBL1244973

O=Cc1cc(F)cs1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2320780 0.76 PGR (0.42)
SCHEMBL30104097 0.76 PGR (0.44)
SCHEMBL346857 0.72
SCHEMBL23006 0.72
SCHEMBL30541257 0.71 ESR1 (0.42)
SCHEMBL9050923 0.71 L3MBTL1 (0.41)
SCHEMBL18830906 0.70
SCHEMBL1363558 0.70
SCHEMBL8222639 0.70
SCHEMBL5211654 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3880659-B1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS AG (CH) 2024-01-03 EP disclosed
US-11718607-B2 Atypical coupling method for the preparation of 1,2-di(thiophen-2-yl)ethene-1,2-diol compounds via a Cu(II) catalyst QATAR UNIVERSITY (QA) 2023-08-08 US disclosed
US-20230051589-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS AG (CH) 2023-02-16 US disclosed
US-20220204487-A1 ATYPICAL COUPLING METHOD FOR THE PREPARATION OF 1,2-DI(THIOPHEN-2-YL)ETHENE-1,2-DIOL COMPOUNDS VIA A CU(II) CATALYST QATAR UNIVERSITY (QA) 2022-06-30 US disclosed
EP-3880659-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY Novartis AG (CH) 2021-09-22 EP disclosed
CN-113286784-A Compounds and compositions for treating conditions associated with NLRP activity 诺华股份有限公司 2021-08-20 CN disclosed
WO-2020102576-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS INFLAMMASOME RESEARCH, INC. (US) 2020-05-22 WO disclosed
WO-2019041047-A1 FLUORINATED DITHIENYL-DIKETOPYRROLOPYRROLE MONOMERS AND POLYMERS AND USES THEREOF UNIVERSITé LAVAL (CA) 2019-03-07 WO disclosed
WO-2019041047-A1 FLUORINATED DITHIENYL-DIKETOPYRROLOPYRROLE MONOMERS AND POLYMERS AND USES THEREOF UNIVERSITé LAVAL (CA) 2019-03-07 WO disclosed
US-7884124-B2 such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions SEPRACOR INC. (US) 2011-02-08 US disclosed
EP-1275630-A1 PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND Mitsui Chemicals, Inc. (JP) 2003-01-15 EP disclosed
CN-1380880-A Process for producing substituted aromatic compound MITSUI CHEMICALS INC (JP) 2002-11-20 CN disclosed
US-20020161227-A1 PROCESS FOR PREPARATION OF SUBSTITUTED AROMATIC COMPOUND MITSUI CHEMICALS, INC. (JP) 2002-10-31 US disclosed
US-6469224-B1 REACTING A PHOSPHAZENIUM COMPOUND WITH A HALOGENATED AROMATIC COMPOUNDS, ESPECIALLY CHLORINATED AROMATIC COMPOUNDS MITSUI CHEMICALS, INC. (JP) 2002-10-22 US disclosed
US-4695634-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1987-09-22 US disclosed
US-4622406-A CHEMICAL INTERMEDIATES, TRIMETHYLSILOXY COMPOUNDS PFIZER INC. (US) 1986-11-11 US disclosed
US-4562267-A Intermediates of hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1985-12-31 US disclosed
US-4423233-A ALPHA-HYDROXY CARBOXIMIDATE INTERMEDIATES PFIZER INC. (US) 1983-12-27 US disclosed
US-4381308-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1983-04-26 US disclosed
US-4332952-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1982-06-01 US disclosed