Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12449728 | 0.93 | KMT2A (0.42) | EPHX2CYP2C9GPR119EPHX1KDM4E | |
| SCHEMBL2346305 | 0.80 | EPHX2 (0.52) | EPHX2CYP2C9GPR119EPHX1TRPM8 | |
| SCHEMBL12449918 | 0.78 | KMT2A (0.44) | EPHX2CYP2C9GPR119EPHX1DRD2 | |
| SCHEMBL12449442 | 0.75 | EPHX2 (0.48) | EPHX2CYP2C9GPR119EPHX1TRPM8 | |
| SCHEMBL2341136 | 0.72 | EPHX2 (0.43) | EPHX2CYP2C9GPR119EPHX1TRPM8 | |
| SCHEMBL2345904 | 0.70 | EPHX2 (0.67) | EPHX2CYP2C9GPR119EPHX1TRPM8 | |
| SCHEMBL18101737 | 0.66 | COXFA4 (0.47) | CYP2C9GAAKMT2A | |
| SCHEMBL20616667 | 0.66 | TRPM8 (0.59) | EPHX2GPR119EPHX1TRPM8DRD2 | |
| SCHEMBL18144736 | 0.66 | GPR119 (0.61) | EPHX2CYP2C9GPR119EPHX1TRPM8 | |
| SCHEMBL15156666 | 0.65 | GPR119 (0.70) | EPHX2CYP2C9GPR119EPHX1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130310389-A1 | SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2013-11-21 | — | — | US | disclosed |
| US-8524713-B2 | Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands | CEPHALON, INC (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524713-B2 | Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands | CEPHALON, INC (US) | 2013-09-03 | — | — | US | disclosed |
| EP-2257553-B1 | SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON INC (US) | 2011-08-31 | — | — | EP | disclosed |
| US-20100298332-A1 | Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON, INC. (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100298332-A1 | Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON, INC. (US) | 2010-11-25 | — | — | US | disclosed |
| WO-2009097309-A1 | SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298332-A1 | Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands | HRH3, HRH4, HRH2 | EPHX2 1028/4885CYP2C9 2368/4885GPR119 118/4885 |
| US-20130310389-A1 | SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | HRH3, HRH4, HRH2 | EPHX2 1736/4885CYP2C9 2506/4885GPR119 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.