⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867548 | 0.77 | — | — | |
| SCHEMBL20852505 | 0.74 | — | — | |
| SCHEMBL6736948 | 0.70 | — | — | |
| SCHEMBL16595162 | 0.65 | — | — | |
| SCHEMBL1938703 | 0.65 | — | — | |
| SCHEMBL6690881 | 0.65 | — | — | |
| SCHEMBL420193 | 0.65 | — | — | |
| SCHEMBL4596022 | 0.65 | — | — | |
| SCHEMBL16438976 | 0.65 | — | — | |
| SCHEMBL13631878 | 0.63 | LMNA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024549-B2 | Compound having affinity substance to soluble protein, cleavable portion and reactive group, or salt thereof | AJINOMOTO CO., INC. (JP) | 2024-07-02 | — | — | US | disclosed |
| US-11737992-B2 | Sphingosine kinase Type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-9974758-B2 | Sphingosine kinase type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| US-20160317472-A1 | Sphingosine Kinase Type 1 Inhibitors and Uses Thereof | ENZO THERAPEUTICS, INC. C/O ENZO BIOCHEM, INC. (US) | 2016-11-03 | — | — | US | disclosed |
| US-9388121-B2 | Sphingosine kinase type 1 inhibitors | ENZO THERAPEUTICS, INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-20130245321-A1 | SPHINGOSINE KINASE TYPE 1 INHIBITORS | VIRGINIA COMMONWEALTH UNIVERSITY | 2013-09-19 | — | — | US | disclosed |
| US-8314151-B2 | Sphingosine kinase type 1 inhibitors, and processes for using same | ENZO THERAPEUTICS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20120237448-A9 | SPHINGOSINE KINASE TYPE 1 INHIBITORS, AND PROCESSES FOR USING SAME | VIRGINIA COMMONWEALTH UNIVERSITY | 2012-09-20 | — | — | US | disclosed |
| US-20100278741-A1 | Novel compositions including sphingosine kinase type 1 inhibitors, and processes for using same | ENZO THERAPEUTICS, INC. C/O ENZO BIOCHEM, INC. | 2010-11-04 | — | — | US | disclosed |