Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244117 | 0.83 | KDM4E (0.51) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL3264194 | 0.75 | DAO (0.44) | DAOSRD5A2KDM4EHSD17B10HPGD | |
| SCHEMBL13175413 | 0.75 | DAO (0.44) | DAOSRD5A2KDM4EHSD17B10HPGD | |
| SCHEMBL27350271 | 0.74 | DAO (0.50) | DAOSRD5A2KDM4EHSD17B10HPGD | |
| SCHEMBL4393058 | 0.71 | DAO (0.47) | DAOSRD5A2KDM4EHSD17B10HPGD | |
| SCHEMBL6627435 | 0.70 | DAO (0.49) | DAOSRD5A2KDM4EHSD17B10HPGD | |
| SCHEMBL20494370 | 0.70 | HSD17B10 (0.60) | DAOSRD5A2KDM4EHSD17B10HPGD | |
| SCHEMBL1244101 | 0.70 | DAO (0.78) | DAOSRD5A2KDM4EHSD17B10HPGD | |
| SCHEMBL1244129 | 0.69 | DAO (0.51) | DAOSRD5A2KDM4EHSD17B10HPGD | |
| SCHEMBL1244189 | 0.69 | SMYD3 (0.54) | DAOSRD5A2KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-20100029741-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2010-02-04 | — | — | US | disclosed |
| US-20100022612-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2010-01-28 | — | — | US | disclosed |
| US-7579370-B2 | Fused heterocycles | SEPRACOR INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004328-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022612-A1 | FUSED HETEROCYCLES | AHR, HAX1, HRH3 | DAO 2452/4885SRD5A2 750/4885KDM4E 3180/4885 |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | DAO, DDO, AOX1 | DAO 1/4885SRD5A2 785/4885KDM4E 2644/4885 |
| US-20100029741-A1 | FUSED HETEROCYCLES | CHRNA4, CHRNB4, CHRNA3 | DAO 1545/4885SRD5A2 394/4885KDM4E 3881/4885 |
| US-20080004328-A1 | FUSED HETEROCYCLES | HRH3, HRH4, AHR | DAO 2936/4885SRD5A2 915/4885KDM4E 3354/4885 |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | DAO, DDO, AOX1 | DAO 1/4885SRD5A2 1151/4885KDM4E 2046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.