SCHEMBL1245084

SCHEMBL1245084

C[Si](C)(C)CC[Si](C)(C)CCCOCC(O)CN1CCOCC1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
USP2 O75604 3/20 0.46
ALDH1A1 P00352 2/20 0.43
TSHR P16473 3/20 0.42
HTT P42858 1/20 0.42
L3MBTL1 Q9Y468 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ALOX15 P16050 1/20 0.41
GAA P10253 2/20 0.40
MAPK1 P28482 1/20 0.40
POLB P06746 1/20 0.40
ADRB2 P07550 1/20 0.40
ADRB1 P08588 1/20 0.40
ADRB3 P13945 1/20 0.40
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
PKM P14618 1/20 0.39
ABCB1 P08183 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12621150 0.88 ALDH1A1 (0.45) USP2ALDH1A1TSHRHTTL3MBTL1
SCHEMBL1244331 0.86 SMN1; SMN2 (0.48) USP2ALDH1A1HTTL3MBTL1SMN1; SMN2
SCHEMBL1244968 0.85 ALDH1A1 (0.42) USP2ALDH1A1HTTL3MBTL1SMN1; SMN2
SCHEMBL22354571 0.83 USP2 (0.62) USP2ALDH1A1TSHRHTTL3MBTL1
SCHEMBL12153680 0.83 ALDH1A1 (0.49) USP2ALDH1A1TSHRHTTL3MBTL1
SCHEMBL16707883 0.83 USP2 (0.47) USP2ALDH1A1TSHRHTTL3MBTL1
SCHEMBL1244276 0.82 TDP1 (0.38) ALDH1A1TSHRADRB2ADRB1ADRB3
SCHEMBL1244429 0.82 ALDH1A1 (0.40) USP2ALDH1A1TSHRHTTL3MBTL1
SCHEMBL15536318 0.81 USP2 (0.45) USP2ALDH1A1TSHRHTTL3MBTL1
SCHEMBL12761114 0.80 USP2 (0.59) USP2ALDH1A1TSHRHTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2124545-B1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MOMENTIVE PERFORMANCE MAT INC (US) 2015-12-02 EP disclosed
EP-2124545-B1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MOMENTIVE PERFORMANCE MAT INC (US) 2015-12-02 EP disclosed
US-8569385-B2 Hydrolysis resistant organomodified silylated ionic surfactants MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2013-10-29 US disclosed
US-8569385-B2 Hydrolysis resistant organomodified silylated ionic surfactants MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2013-10-29 US disclosed
US-8569385-B2 Hydrolysis resistant organomodified silylated ionic surfactants MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2013-10-29 US disclosed
US-20110105428-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2011-05-05 US disclosed
US-7879916-B2 Anionic, cationic or zwitterionic disilane surfactants; stable over a wide pH range; for controlling wetting, spreading, foaming, and detergency on applied surfaces; aqueous solutions improve delivery of active ingredients MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2011-02-01 US disclosed
US-7879916-B2 Anionic, cationic or zwitterionic disilane surfactants; stable over a wide pH range; for controlling wetting, spreading, foaming, and detergency on applied surfaces; aqueous solutions improve delivery of active ingredients MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2011-02-01 US disclosed
EP-2124545-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS Momentive Performance Materials Inc. (US) 2009-12-02 EP disclosed
EP-2124544-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS Momentive Performance Materials Inc. (US) 2009-12-02 EP disclosed
US-20080167269-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-07-10 US disclosed
US-20080167269-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-07-10 US disclosed
US-20080167389-A1 Hydrolysis resistant organomodified silylated ionic surfactants MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-07-10 US disclosed
US-20080167389-A1 Hydrolysis resistant organomodified silylated ionic surfactants MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-07-10 US disclosed
WO-2008073396-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-06-19 WO disclosed
WO-2008073397-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-06-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110105428-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MLNR, SSTR3, FOXM1 USP2 664/4885ALDH1A1 2282/4885TSHR 309/4885
US-20080167389-A1 Hydrolysis resistant organomodified silylated ionic surfactants MLNR, SSTR3, FOXM1 USP2 664/4885ALDH1A1 2282/4885TSHR 309/4885
US-20080167269-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED IONIC SURFACTANTS MLNR, SSTR3, FOXM1 USP2 664/4885ALDH1A1 2282/4885TSHR 309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.