Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149017 | 0.89 | CYP1A2 (0.47) | LMNAMAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL16545853 | 0.78 | ESR1 (0.48) | MAPTALDH1A1KDM4EALOX15HSD17B10 | |
| SCHEMBL8829522 | 0.77 | ALOX5 (0.45) | CYP1A2NQO1TAAR1 | |
| SCHEMBL10366435 | 0.76 | MAOA (0.41) | LMNAMAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL14321667 | 0.75 | VKORC1 (0.37) | LMNAMAPTHPGDALOX15KMT2A | |
| SCHEMBL7752320 | 0.72 | IDH1 (0.42) | LMNAALDH1A1POLBNQO1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11522917 | 0.70 | IDH1 (0.41) | LMNAALDH1A1POLBNQO1SMN1; SMN2 | |
| SCHEMBL9861098 | 0.70 | MAPK1 (0.42) | LMNAALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL3895689 | 0.69 | TSHR (0.47) | ALDH1A1CYP1A2CYP2C9MAPK1HIF1A | |
| SCHEMBL14327853 | 0.68 | XIAP (0.39) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238549-A1 | Nuclear Hormone Receptor Modulators | ABBOTT LABORATORIES (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120238549-A1 | Nuclear Hormone Receptor Modulators | ABBOTT LABORATORIES (US) | 2012-09-20 | — | — | US | disclosed |
| WO-2012125797-A1 | NUCLEAR HORMONE RECEPTOR MODULATORS | ABBOTT LABORATORIES (US) | 2012-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238549-A1 | Nuclear Hormone Receptor Modulators | NR5A1, NR5A2, NR3C2 | LMNA 2541/4885MAPT 4409/4885ALDH1A1 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.