Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 4/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12457724 | 0.89 | LMNA (0.48) | CYP1A2CYP2C9MAPK1HIF1ATAAR1 | |
| SCHEMBL16545853 | 0.85 | ESR1 (0.48) | ALDH1A1MAPTIDH1 | |
| SCHEMBL14321667 | 0.81 | VKORC1 (0.37) | TAAR1LMNAMAPT | |
| SCHEMBL14327853 | 0.77 | XIAP (0.39) | TAAR1TSHRMAP1LC3B | |
| SCHEMBL9861098 | 0.77 | MAPK1 (0.42) | CYP1A2CYP2C9MAPK1HIF1ATAAR1 | |
| SCHEMBL3895689 | 0.72 | TSHR (0.47) | CYP1A2CYP2C9MAPK1HIF1ATSHR | |
| SCHEMBL10366435 | 0.72 | MAOA (0.41) | CYP1A2CYP2C9MAPK1HIF1ATSHR | |
| SCHEMBL17480820 | 0.69 | CYP1A2 (0.44) | CYP1A2CYP2C9MAPK1HIF1ACALM1 | |
| SCHEMBL12028696 | 0.67 | CYP1A2 (0.57) | CYP1A2CYP2C9MAPK1HIF1ALMNA | |
| SCHEMBL7121422 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038612-B1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-07-29 | — | — | EP | disclosed |
| US-10351511-B2 | Cyclic vinylogous amides as bromodomain inhibitors | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-07-16 | — | — | US | disclosed |
| US-20180105485-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-04-19 | — | — | US | disclosed |
| US-20180105485-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-04-19 | — | — | US | disclosed |
| US-9884806-B2 | Cyclic vinylogous amides as bromodomain inhibitors | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-02-06 | — | — | US | disclosed |
| US-9884806-B2 | Cyclic vinylogous amides as bromodomain inhibitors | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-02-06 | — | — | US | disclosed |
| US-9643919-B2 | Cycloalkyl-dione derivatives and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643919-B2 | Cycloalkyl-dione derivatives and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643919-B2 | Cycloalkyl-dione derivatives and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-05-09 | — | — | US | disclosed |
| US-20160200666-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160200666-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-07-14 | — | — | US | disclosed |
| WO-2015031824-A9 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-06-16 | — | — | WO | disclosed |
| US-20160031805-A1 | CYCLOALKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
| US-20160031805-A1 | CYCLOALKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
| US-20160031805-A1 | CYCLOALKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
| WO-2015031824-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2015-03-05 | — | — | WO | disclosed |
| WO-2014165633-A1 | CYCLOAKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLAVANIA (US) | 2014-10-09 | — | — | WO | disclosed |
| WO-2014165633-A1 | CYCLOAKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLAVANIA (US) | 2014-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200666-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | BRD1, BRD4, BRDT | CYP1A2 3501/4885CYP2C9 4262/4885MAPK1 2122/4885 |
| US-10351511-B2 | Cyclic vinylogous amides as bromodomain inhibitors | BRD1, BRD4, BRDT | CYP1A2 3501/4885CYP2C9 4262/4885MAPK1 2122/4885 |
| US-20160031805-A1 | CYCLOALKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE | CYP1B1, SQLE, C1S | CYP1A2 11/4885CYP2C9 109/4885MAPK1 1497/4885 |
| US-20180105485-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | BRD1, BRD4, BRDT | CYP1A2 3501/4885CYP2C9 4262/4885MAPK1 2122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.