Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 3/20 | 0.34 |
| ▸ | CCR8 | P51685 | 3/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25776767 | 0.89 | CYP19A1 (0.38) | CYP19A1TBXAS1NOS3NOS1NOS2 | |
| SCHEMBL27890627 | 0.81 | CYP19A1 (0.47) | CYP19A1TBXAS1NOS3NOS1NOS2 | |
| SCHEMBL13409634 | 0.80 | NOS3 (0.39) | CYP19A1TBXAS1NOS3NOS1NOS2 | |
| SCHEMBL28010992 | 0.77 | CYP19A1 (0.47) | CYP19A1TBXAS1CCR1CCR8CCR5 | |
| SCHEMBL24097109 | 0.77 | CYP19A1 (0.43) | CYP19A1TBXAS1 | |
| Hydrochloric Acid SCHEMBL27549267 | 0.76 | CYP19A1 (0.46) | CYP19A1TBXAS1CCR1CCR8CCR5 | |
| SCHEMBL22579802 | 0.74 | TDP1 (0.42) | CYP19A1TBXAS1CCR1CCR8CCR5 | |
| SCHEMBL3860294 | 0.73 | CYP19A1 (0.43) | CYP19A1TBXAS1CYP3A4HTT | |
| SCHEMBL3892087 | 0.71 | CYP19A1 (0.60) | CYP19A1TBXAS1TDP1GAAL3MBTL1 | |
| SCHEMBL28125072 | 0.71 | L3MBTL1 (0.40) | CYP19A1TBXAS1TDP1TDP2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249449-A1 | SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2021-12-16 | — | — | WO | disclosed |
| WO-2011097166-A2 | COMBINATION THERAPY FOR TREATING CANCER COMPRISING AN IGF-1R INHIBITOR AND AN HDAC INHIBITOR | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-08-11 | — | — | WO | disclosed |
| US-20110077265-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077265-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC2 | CYP19A1 4303/4885TBXAS1 2996/4885NOS3 3570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.